Candidate gene expression in response to low-level air pollution

Environment International
Lina MadaniyaziYuming Guo

Abstract

Epidemiological studies have linked air pollutant to adverse health effects even at low exposure levels, but limited evidence is available on its associations with gene expression levels. To investigate associations between air pollutants and gene expression levels. We collected data from Brisbane System Genetics Study (BSGS) - a family-based system genetics study. Expression levels of candidate genes were obtained for whole blood from 266 pairs of twins (192 monozygotic and 74 dizygotic pairs) and 165 parents. Data on individual phenotypes were also obtained, including age, sex, Body Mass Index and exposure to smoke. Daily data on mean temperature and air pollutants, including particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5), ozone (O3), nitrogen dioxide (NO2) and sulfur dioxide (SO2), were collected from seven monitoring stations for the day when the blood samples were collected. The association between each air pollutant and expression level of each gene was analyzed by using generalized linear models with adjustment for temperature and individual phenotypes, and its difference between monozygotic and dizygotic twins was investigated. The mean value for daily concentration of air pollutants were 5.9 µg/m3 for PM2...Continue Reading

References

Nov 1, 2005·Regulatory Toxicology and Pharmacology : RTP·Juli Bai, Ziqiang Meng
Mar 12, 2008·Carcinogenesis·Danitsja M van LeeuwenJos C S Kleinjans
Jan 18, 2011·Journal of Toxicology and Environmental Health. Part a·Yuh-Chin T HuangRobert B Devlin
Mar 19, 2011·Progress in Cardiovascular Diseases·Antonella ZanobettiJoel Schwartz
Mar 13, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·John W HollowayIan A Yang
May 9, 2012·PloS One·Joseph E PowellGrant W Montgomery
May 9, 2013·Environmental and Molecular Mutagenesis·Sam De CosterNicolas van Larebeke
Jan 8, 2015·Journal of Exposure Science & Environmental Epidemiology·Sharine WittkoppRalph J Delfino
May 30, 2015·PloS One·Anita GoldingerJoseph E Powell
Feb 6, 2017·Epidemiology·Nahid MostafaviRoel Vermeulen
Jun 29, 2017·The New England Journal of Medicine·Qian DiJoel D Schwartz
Aug 16, 2017·Environmental Science and Pollution Research International·Panhong GouSa Liu
Aug 20, 2017·Environmental Health : a Global Access Science Source·Ellen WinckelmansKaren Vrijens
Dec 11, 2017·The Science of the Total Environment·Gongbo ChenShanshan Li
Dec 28, 2017·JAMA : the Journal of the American Medical Association·Qian DiFrancesca Dominici
Jul 7, 2018·Environmental Pollution·Almudena Espín-PérezTheo M C M de Kok
Sep 28, 2018·Genome Biology·Daniel L McCartneyRiccardo E Marioni

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Citations

Jun 18, 2021·Chronic Diseases and Translational Medicine·Lina Madaniyazi, Seposo Xerxes
Jul 16, 2021·Environmental Pollution·Shin ArakiUNKNOWN Japan Environment and Children's Study Group

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