Candidate Gene, Genome-Wide Association and Bioinformatic Studies in Pre-eclampsia: a Review

Current Hypertension Reports
Semone ThakoordeenThajasvarie Naicker

Abstract

Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development. It is apparent that different genes show significance in varying populations. Notably, it is reported that apolipoprotein-1 gene polymorphisms are associated with pre-eclampsia development in an African-American population, which may be worthwhile to investigate in a Black South African cohort. Despite the research attention that is focused on this surreptitious syndrome, a definitive cause eludes scientists and physicians, alike. Genetic studies can fulfil a dual purpose of suggesting novel hypotheses through genome-wide screening and testing these hypotheses via candidate gene studies. However, publications to date have only presented inconsistent and conflicting results regarding candidate gene analysis.

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Citations

Nov 6, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gillian M MaherGerard W O'Keeffe
May 15, 2020·International Journal of Molecular Sciences·Yury A BarbitoffAndrey S Glotov
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