Candidate gene region 15q26 and genetic susceptibility to coeliac disease in Finnish families

Scandinavian Journal of Gastroenterology
M SusiJ Partanen

Abstract

Studies in the Irish and British populations have indicated that chromosome region 15q26 could include a novel non-HLA-linked locus conferring genetic susceptibility to coeliac disease. The locus is of particular interest, since a type I diabetes risk locus, IDDM3, maps to the same position. It was tested whether this locus shows evidence for genetic linkage to coeliac disease in Finland. Ninety-nine Finnish families with at least one affected sibpair were studied. Five microsatellite markers mapped within approximately 20 cM region on chromosome 15q26 were typed. Non-parametric linkage (NPL) scores and allelic transmission (TDT) were studied. No evidence for genetic linkage could be obtained by the NPL scores calculated by the Genehunter program. However, transmission/disequilibrium analysis (TDT) revealed that haplotype D15S107*1-D15S120*6 was statistically significantly more frequently transmitted to affected than expected by chance (TDT chi2 9.0; P = 0.003). The subgroup of families having this haplotype, however, did not differ from the others, regarding to disease manifestation, HLA status, or geographical origin. The 15q26 region appears not to be a major non-HLA susceptibility locus for gluten sensitivity in Finland, bu...Continue Reading

References

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Citations

Jul 26, 2002·Genes and Immunity·F Pociot, M F McDermott
Feb 28, 2014·Molecular Medicine Reports·Lei HeNing Jia
May 21, 2013·Journal of Lipid Research·Choon Young Kim, Kee-Hong Kim
Oct 18, 2005·Nature Genetics·Joanne E CurranJohn Blangero

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