Candidates for inclusion in a universal antiretroviral regimen: dolutegravir

Current Opinion in HIV and AIDS
Pedro Cahn

Abstract

The review addresses the role of dolutegravir (DTG) in first-line therapy. In the era of test and treat, where United Nations AIDS Program and WHO have set the ambitious targets of 90/90/90, new efficacious, well tolerated, and simple therapeutic options are needed. DTG has been tested in large clinical trials in treatment-naïve patients, showing noninferiority to raltegravir and superiority compared with efavirenz and ritonavir-boosted darunavir, respectively. The main features of DTG are reviewed in this study, including efficacy, safety, high-resistance barrier, daily treatment schedule, and coformulation as single-tablet regimen. Use of DTG in special populations is also reviewed. Tolerability, with focus in neuropsychiatric disturbances is discussed in particular. DTG has shown high efficacy level, tested in males and females, has no limitations in patients with renal and/or hepatic impairment and is available as single drug (to be combined with two nucleoside reverse transcriptase inhibitors in fixed combinations) or as a single-tablet regimen combined with abacavir and lamivudine. DTG is an excellent candidate for initial therapy in HIV-infected patients. If safety of DTG in pregnant women are confirmed by ongoing studie...Continue Reading

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Citations

May 15, 2018·Angewandte Chemie·Robert E ZieglerTimothy F Jamison
Apr 21, 2017·Current Opinion in HIV and AIDS·Amy L SlogroveElaine J Abrams
Dec 6, 2017·Pharmacogenomics·Jessica CusatoAntonio D'Avolio
Nov 14, 2017·Journal of the International AIDS Society·Wafaa M El-SadrDeborah L Birx
May 18, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emilie R ElliotMarta Boffito
Mar 20, 2018·Current Opinion in HIV and AIDS·Hsin-Yun SunChien-Ching Hung
May 10, 2017·Current Opinion in HIV and AIDS·Charles W FlexnerWillem D F Venter
Sep 21, 2018·Expert Opinion on Pharmacotherapy·Ying MuTheodore J Cory
Jan 30, 2019·Reaction Chemistry & Engineering·Cameron T ArmstrongThomas D Roper

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