PMID: 9176973May 1, 1997Paper

Candidemia in acute leukemia patients

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
P RibeiroJ Gouveia

Abstract

Fungal infections are an important cause of morbidity and mortality in patients with acute leukemia (AL). Candidemia, once rare, is now a common nosocomial infection because of the intensity of chemotherapy, prolonged neutropenia, administration of broad-spectrum antibiotics and use of central venous catheters (CVC). We retrospectively identified patients treated for AL from 6/86 to 6/95 who also had candidemia. We describe 28 patients (incidence 6.3%) with a median age of 39 years, 24 of whom were on remission induction and 4 on postremission chemotherapy. All patients had CVC and empiric antimicrobial therapy, 4 had been given prophylactic antifungal drugs, and 2 had parenteral nutrition. Neutropenia was profound (median leukocyte nadir 200/microliters, median duration 19 days). Candida was isolated in blood cultures 10 days (median) after the start of neutropenia. The clinical presentation included fever (100%), respiratory symptoms (71.4%), skin lesions (39.2%) and septic shock (17.8%). Amphotericin B was given to 17 patients and liposomal amphotericin to 5 patients. Infection resolved in 18 patients (64.2%). 10 of whom were in complete remission. Mortality from candidemia was 17.8% (5/28). In conclusion, fungal infections ...Continue Reading

Citations

Jan 26, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Patrícia RibeiroAida B Sousa
Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G A YoungS Durrant
Dec 17, 2008·Future Microbiology·Rosalía Diez-Orejas, Elena Fernández-Arenas
Jan 1, 2006·The Libyan Journal of Medicine·Ka Al-Anazi, Am Al-Jasser
Jun 25, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L PaganoP Viale
Jun 6, 2014·PloS One·Hung-Jen TangChih-Cheng Lai
Apr 29, 2005·Journal of Leukocyte Biology·Brad J SpellbergAshraf S Ibrahim
Dec 13, 2006·Journal of Leukocyte Biology·Brad J SpellbergAshraf S Ibrahim
Mar 23, 2018·Journal of Fungi·Rukumani Devi VelayuthanDavid W Denning
Oct 4, 2000·Journal of Clinical Microbiology·G W ProcopG D Roberts

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