Canine cerebrospinal fluid total nucleated cell counts and cytology associations with the prevalence of magnetic resonance imaging abnormalities

Veterinary Medicine
Timothy B HugoRobert H Labuc

Abstract

The combination of cerebrospinal fluid (CSF) analysis and magnetic resonance imaging (MRI) are often used to investigate intracranial disease in dogs. The aim of this retrospective study was to determine if the total nucleated cell count (TNCC) or cytology findings in abnormal CSF are associated with the prevalence of MRI abnormalities. For each case, the TNCC was categorized into one of three groups: A (<25×106/L); B (25-100×106/L); and C (>100×106/L). Cytology findings were categorized by the predominant cell type as lymphocytic, monocytoid, neutrophilic, or eosinopilic. MRI descriptions were classified as either normal or abnormal, and abnormal studies were further evaluated for the presence of specific characteristics (multifocal or diffuse disease versus focal disease, positive T2-weighted hyperintensity, positive FLAIR hyperintensity, contrast enhancement, mass effect, and the presence of poorly or well-defined lesion margins). Forty-five dogs met the inclusion criteria and MRI abnormalities were found in 29/45 (64%) dogs. TNCCs were not associated with the prevalence of MRI abnormalities or specific characteristics. Cytology categories were significantly associated with the prevalence of MRI abnormalities (P<0.001). Spec...Continue Reading

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R Statistical Computing
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