Canine conceptus-maternal communication during maintenance and termination of pregnancy, including the role of species-specific decidualization.

Theriogenology
Mariusz P KowalewskiA Kazemian

Abstract

Among domestic animal species, the reproductive biology of the dog belongs to the most peculiar. This includes the conceptus-maternal communication and endocrine mechanisms involved in maintenance of pregnancy. Dogs fully depend on luteal progesterone (P4) throughout pregnancy, with similar steroid secretion patterns in pregnant and non-pregnant bitches until prepartum luteolysis. Thus, dogs lack the classical recognition of pregnancy. The luteal P4 is the most important hormone regulating the onset and maintenance of pregnancy in previously estrogenized bitches. Although the canine uterus is exposed to high P4 levels, decidualization is not spontaneous but induced by the presence of embryos. Following implantation, decidualization continues, associated with development of the invasive endotheliochorial placenta, leading to establishment of maternal decidual cells expressing the nuclear P4 receptor (PGR). Consequently, although not producing steroids, the canine placenta remains highly sensitive to circulating ovarian steroids. The placental conceptus-maternal communication is responsible for the maintenance of pregnancy, with functional withdrawal of PGR evoking a luteolytic cascade with prepartum PGF2α release. The fetal trop...Continue Reading

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Citations

Dec 5, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Mariusz P KowalewskiAykut Gram
Feb 27, 2021·Frontiers in Veterinary Science·Miguel Tavares PereiraMariusz P Kowalewski
Apr 9, 2021·Cell and Tissue Research·Lea Magdalena RempelSandra Goericke-Pesch
Aug 17, 2021·Theriogenology·Priscila SilvaMarcus Antônio Rossi Feliciano
Oct 28, 2021·Reproduction in Domestic Animals = Zuchthygiene·Miguel Tavares PereiraMariusz Pawel Kowalewski

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