PMID: 7512738Feb 3, 1994Paper

Canine galanin: sequence, expression and pancreatic effects

Regulatory Peptides
M R BoyleG J Taborsky

Abstract

To determine if dog galanin is a potent inhibitor of dog insulin secretion we determined its primary structure from its cloned cDNA, evaluated its expression in celiac ganglia and determined its effect on islet hormone secretion. The predicted amino acid sequence differs from the other known species of galanin by three to six amino acids in the C-terminal half of the molecule. In situ hybridization revealed the presence of dog progalanin mRNA in every neuronal cell body in the dog celiac ganglion. The predicted dog galanin peptide was synthesized and infused i.v. at 0.25, 2.5, 25 or 250 pmol/kg/min. It potently inhibited insulin secretion, less potently inhibited pancreatic somatostatin release and stimulated glucagon secretion, similar to the effects of porcine galanin in the dog. In summary, dog galanin is expressed in the neuronal cell bodies that innervate the pancreas and the sequence of the dog galanin preserves the potent insulin inhibitory part of the galanin molecule. These data support the hypothesis that galanin is a sympathetic neurotransmitter in dog pancreas.

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Citations

Jan 1, 1996·Peptides·C BartonG A Bray
Nov 17, 1995·Neuroscience Letters·J LundkvistT Bartfai
Aug 8, 2001·Journal of Neuroendocrinology·E Adeghate, A S Ponery
Feb 3, 1999·Annals of the New York Academy of Sciences·U Langel, T Bartfai
Oct 27, 2015·Histochemistry and Cell Biology·P PodlaszJ Kaleczyc
Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Yuh-Lin YuYung-Hsi Kao
Apr 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Savio G BarretoGino T P Saccone
Sep 26, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Savio G BarretoGino T P Saccone
Jan 22, 1998·The American Journal of Physiology·T O MundingerG J Taborsky
Sep 26, 1997·The Journal of Biological Chemistry·K E SmithC Gerald

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