Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

Breast Cancer Research and Treatment
Frédérique NguyenJérome Abadie

Abstract

Dogs have been proposed as spontaneous animal models of human breast cancer, based on clinicopathologic similarities between canine and human mammary carcinomas. We hypothesized that a better knowledge of the natural history and prognostic factors of canine invasive mammary carcinomas would favor the design of preclinical trials using dogs as models of breast cancer. The 2-year outcome of 350 female dogs with spontaneous invasive mammary carcinoma was studied. The investigated prognostic factors included age at diagnosis, pathologic tumor size, pathologic nodal stage, lymphovascular invasion, histological grade, and expression of Estrogen Receptor alpha (ERα), Progesterone Receptor, Ki-67, Human Epidermal Growth Factor Receptor 2, basal cytokeratins 5/6, and Epidermal Growth Factor Receptor. Multivariate survival analyses were performed using the Cox proportional hazards model. The overall survival after mastectomy was 11 months. Within 1 year post mastectomy, 41.5% of dogs (145/350) died from their mammary carcinoma. By multivariate analysis, the significant prognostic factors for overall survival included a pathologic tumor size larger than 20 mm [HR 1.47 (95% confidence interval 1.15-1.89)], a positive nodal stage [pN+, HR 1...Continue Reading

References

Apr 1, 1976·Journal of the National Cancer Institute·W Misdorp, A A Hart
Nov 1, 1986·Veterinary Pathology·J E MoultonM Goldman
Nov 1, 1996·The Journal of Veterinary Medical Science·T YamagamiM Sugiyama
Jul 31, 1998·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L L PeñaM Castaño
Dec 7, 2000·Cancer Investigation·D M Vail, E G MacEwen
Sep 25, 2003·Breast Cancer Research and Treatment·J Martin de las MulasS Ramón y Cajal
Nov 2, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P DutraG D Cassali
Apr 5, 2005·The Journal of Veterinary Medical Science·Teruo ItohHiroki Shii
Oct 6, 2005·Journal of Comparative Pathology·M KarayannopoulouA Dessiris
Nov 30, 2005·Journal of the American Veterinary Medical Association·Shih-Chieh ChangMin-Liang Wong
Aug 28, 2007·Nature Reviews. Cancer·Tracy Vargo-Gogola, Jeffrey M Rosen
Jan 18, 2008·Veterinary Surgery : VS·Nina StratmannAxel Wehrend
Jan 19, 2008·Nature Reviews. Cancer·Melissa Paoloni, Chand Khanna
Jun 20, 2008·Journal of Veterinary Internal Medicine·D F MerloV Bocchini
Mar 7, 2009·The Veterinary Journal·Adelina GamaFernando Schmitt
Mar 31, 2009·BMC Genomics·Paolo UvaEmanuele de Rinaldis
Aug 18, 2009·Journal of the American Veterinary Medical Association·Chao-Chin ChangShih-Chieh Chang
Jan 30, 2010·BMC Veterinary Research·Francesco SassiGiuseppe Sarli
Dec 15, 2010·Veterinary Pathology·P Rivera, H von Euler
Dec 24, 2010·Acta Veterinaria Scandinavica·Wanessa L F TavaresGeovanni D Cassali
Jan 27, 2011·Veterinary Pathology·M GoldschmidtV Zappulli
Nov 15, 2011·Veterinary and Comparative Oncology·M Szczubiał, W Łopuszynski
Feb 22, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Salomé S PinhoFátima Gärtner
Apr 27, 2012·American Journal of Veterinary Research·Andreia A SantosAugusto J F de Matos
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Ahad MuhammadnejadIraj Sohrabi Haghdoost
Jun 29, 2013·Cellular Oncology (Dordrecht)·Sara BravacciniDino Amadori
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Marc J van de Vijver
Apr 17, 2014·Veterinary and Comparative Oncology·C M TranA E Frimberger
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray

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Citations

Dec 19, 2018·Veterinary Pathology·Bernadette RogezValérie Chopin
Jan 22, 2020·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elie DagherFrédérique Nguyen
Jan 12, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Marília C A MachadoAlessandra Estrela-Lima
Sep 11, 2019·Veterinary and Comparative Oncology·Clarissa ZamboniMassimo Castagnaro
Apr 27, 2020·Veterinary and Comparative Oncology·Nieves PastorMaría Esther Durán
Jul 3, 2019·Molecular Biology Reports·Afnan SaleemRatan Kumar Choudhary
Dec 4, 2019·Frontiers in Veterinary Science·Florian ChocteauFrédérique Nguyen
Sep 22, 2020·Veterinary and Comparative Oncology·Florian ChocteauFrédérique Nguyen
Aug 8, 2018·Veterinary Sciences·Liliana M E FinocchiaroGerardo C Glikin
Jul 19, 2020·Nature Communications·Tae-Min KimSangwoo Kim
Apr 2, 2020·Journal of Veterinary Science·Marcela Valko-RokytovskáZuzana Kostecká
Sep 17, 2020·Nature Reviews. Cancer·Amy K LeBlanc, Christina N Mazcko
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Enni Markkanen
Nov 17, 2020·Frontiers in Veterinary Science·Patrícia de Faria LainettiCarlos Eduardo Fonseca-Alves
Dec 17, 2020·Animals : an Open Access Journal From MDPI·Florin StanCristian Martonos
Feb 15, 2021·Research in Veterinary Science·Francesca ParisiAlessandro Poli
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrícia F LainettiFabiana F Souza
Mar 4, 2021·Animals : an Open Access Journal From MDPI·Cristian G TorresPamela Cruz
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Mar 27, 2021·Veterinary Pathology·Giancarlo AvallonePaola Roccabianca
May 1, 2021·Animals : an Open Access Journal From MDPI·Barbara BrunettiLuisa Vera Muscatello
Jun 3, 2021·International Journal of Molecular Sciences·Shin-Ae LeeJe-Yoel Cho
May 27, 2021·BMC Veterinary Research·R Sánchez-CéspedesY Millán
Jul 3, 2021·Pharmaceutics·Antonio Fernando Leis-FilhoRenée Laufer-Amorim
Aug 4, 2021·Journal of Comparative Pathology·Byung-Joon SeungJung-Hyang Sur
Sep 4, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Adeline N BoettcherChristopher K Tuggle
Sep 24, 2021·Veterinary and Comparative Oncology·Krzysztof KowalBrygida Ślaska
Nov 18, 2021·Veterinary Research Communications·Eman S RamadanMarwa S Khattab

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