Canine leucocyte histamine release: response to antigen and to anti-IgE

Veterinary Immunology and Immunopathology
H A JacksonR E Halliwell

Abstract

Histamine release from canine leucocyte-enriched peripheral blood preparations was measured in atopic, non-atopic and artificially sensitised dogs after immunological challenge with D. farinae antigen and anti-IgE. Total cell histamine and spontaneous histamine release was also measured. The total cell histamine content of equal leucocyte preparations was not statistically significant between the atopic and non-atopic groups. At all dilutions of antigen a higher amount of histamine was released from the leucocytes of atopic dogs than was seen in the non-atopic group. No histamine release in response to D. farinae was seen in the sensitised dogs although a statistically significant increase in serum D. farinae-specific IgE could be demonstrated after sensitisation (P < 0.03). Histamine release in response to anti-IgE was significantly greater in the atopic dogs than the non-atopic dogs (P < 0.004) and the sensitised dogs (P < 0.003). There was no statistically significant difference in total serum IgE between the groups. The authors conclude that the leucocytes of atopic dogs have a greater tendency to release histamine than those of normal and artificially sensitised dogs and that this is independent of the concentration of tot...Continue Reading

References

May 1, 1992·Veterinary Immunology and Immunopathology·J S Nimmo WilkieP J Pascoe
Feb 1, 1986·The Journal of Allergy and Clinical Immunology·G MaroneM Condorelli
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·G MaroneS Bonini
May 1, 1988·The Journal of Allergy and Clinical Immunology·L M Lichtenstein
Apr 1, 1989·The Journal of Allergy and Clinical Immunology·K Akagi, R G Townley
Nov 1, 1989·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·B H Thiers
May 1, 1986·American Journal of Hematology·M A BaumannR H Keller
Feb 1, 1985·Veterinary Immunology and Immunopathology·R E Halliwell, S J Longino
May 1, 1983·The Journal of Allergy and Clinical Immunology·J M ButlerJ M Hanifin
Jan 1, 1995·Veterinary Immunology and Immunopathology·P B HillD J DeBoer

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Citations

May 25, 2005·Veterinary Immunology and Immunopathology·S Gilbert, R E W Halliwell
Sep 13, 2001·Veterinary Immunology and Immunopathology·R Marsella, T Olivry
Sep 13, 2001·Veterinary Immunology and Immunopathology·R E Halliwell, D J DeBoer
Jul 10, 1998·Veterinary Immunology and Immunopathology·S Gilbert, R E Halliwell
Jan 8, 1999·Veterinary Immunology and Immunopathology·T M Lian, R E Halliwell
Apr 23, 2003·Clinics in Dermatology·Rosanna Marsella, Thierry Olivry
Apr 10, 2008·The Veterinary Journal·N DévaudI A Burgener
Mar 3, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonRosanna Marsella
Apr 8, 2003·The Journal of Veterinary Medical Science·Rinei IshidaHajime Tsujimoto
Jun 21, 2019·Veterinary Dermatology·Sujeet K ChaudharySatish K Garg

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