Canine mammary carcinomas: influence of histological grade, vascular invasion, proliferation, microvessel density and VEGFR2 expression on lymph node status and survival time

Veterinary and Comparative Oncology
M E DiesslerJ R Idiart

Abstract

Spontaneous invasive non-inflammatory canine mammary carcinomas (CMC) and their regional lymph nodes (LN) were analysed (n = 136). Histological grade (HG) and vascular invasion (VI) in the tumours and lymph node status were recorded. Proliferation index (PI), microvessel density (MVD) and vascular endothelial growth factor receptor 2 (VEGFR2) expression were estimated using anti-proliferating cell nuclear antigen (PCNA), anti-von Willebrand factor and anti-Flk-1, respectively. Eighteen months follow-up was performed (34 bitches). Tumours of different grades showed differences regarding PI, Flk-1/integrated optical density (Flk-1/IOD) and MVD. Every feature showed significant association with LN status through bivariate analyses. From multivariate analyses, VI and Flk-1/IOD were selected to predict LN status. Data revealed that the probability of a CMC-bearing bitch to remain alive at 1, 4, 5 and 14-18 months was 0.91, 0.87, 0.81 and 0.77, respectively. Besides LN status, VI was the only feature positively correlated with survival time, although a trend to shorter survival of animal patients bearing high expressing VEGFR2 CMC was noted.

References

Jul 31, 1998·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L L PeñaM Castaño
Nov 10, 1998·Journal of Comparative Pathology·M CastagnaroM Caramelli
Mar 14, 2000·Veterinary Pathology·Y FunakoshiK Doi
Jun 1, 2000·Journal of Veterinary Internal Medicine·R C Rosenthal
Sep 8, 2000·The Journal of Small Animal Practice·M D Perez AlenzaA I Nieto
Jan 5, 2002·Breast Cancer Research and Treatment·T KatoM Kobayashi
Jul 20, 2002·Veterinary Pathology·B RestucciG De Vico
Feb 5, 2003·Journal of Veterinary Internal Medicine·Jeffrey C PhilibertDavid J Waters
Apr 12, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Giuseppe SarliPaolo Stefano Marcato
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jun 28, 2003·Journal of Cell Science·Giovanni Maga, Ulrich Hubscher
Mar 9, 2004·Journal of Comparative Pathology·B RestucciS Papparella
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan P Schneider, Kathy D Miller
Mar 15, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Daniel J SchoeffnerUnnur P Thorgeirsson
Apr 5, 2005·The Journal of Veterinary Medical Science·Teruo ItohHiroki Shii
Oct 6, 2005·Journal of Comparative Pathology·M KarayannopoulouA Dessiris
Nov 30, 2005·Journal of the American Veterinary Medical Association·Shih-Chieh ChangMin-Liang Wong
May 6, 2008·The Breast : Official Journal of the European Society of Mastology·R Stuart-HarrisP Pharoah
Mar 17, 2009·International Journal of Oncology·Mathias Felix Leber, Thomas Efferth
Mar 1, 2005·Veterinary and Comparative Oncology·J WinstonP J Bergman
Sep 8, 2009·Topics in Companion Animal Medicine·Cheryl A London
Jun 24, 2010·Journal of Comparative Pathology·A A F SantosA J F Matos
Aug 3, 2010·The Veterinary Journal·Felisbina L QueirogaCarlos S Lopes
Oct 12, 2010·Journal of Proteome Research·Robert KlopfleischAchim D Gruber
Dec 15, 2010·Veterinary Pathology·R KlopfleischA D Gruber
Jan 27, 2011·Veterinary Pathology·M GoldschmidtV Zappulli
Jun 8, 2011·Reproduction in Domestic Animals = Zuchthygiene·N SleeckxL Van Brantegem
Nov 15, 2011·Veterinary and Comparative Oncology·M Szczubiał, W Łopuszynski
Apr 27, 2012·Veterinary and Comparative Oncology·T RaposoF L Queiroga
May 17, 2012·Advances in Cancer Research·Annamaria Rapisarda, Giovanni Melillo

❮ Previous
Next ❯

Citations

Nov 1, 2017·Breast Cancer Research and Treatment·Frédérique NguyenJérôme Abadie
Apr 9, 2020·Journal of Veterinary Internal Medicine·Hiroki YamazakiHideo Akiyoshi
Jan 11, 2020·Frontiers in Oncology·Maria Carolina Mangini PradoCarlos Eduardo Fonseca-Alves
Sep 22, 2020·Veterinary and Comparative Oncology·Florian ChocteauFrédérique Nguyen
Dec 4, 2019·Frontiers in Veterinary Science·Florian ChocteauFrédérique Nguyen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.