Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Ana CanadasPatrícia Dias-Pereira

Abstract

Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little is known regarding their influence on canine mammary tumor risk. We assessed the influence of SNPs in genes related to human breast cancer susceptibility, with respect to the risk of development of mammary tumors in dogs. Sixty-seven canine SNPs in proto-oncogenes, tumor suppressor genes, genes involved in DNA repair, and in hormonal metabolism were evaluated in 212 bitches with mammary tumors and in 161 bitches free of mammary neoplasia. A significant association with mammary neoplasia risk was identified for 2 SNPs in RAD51 ( rs23623251 and rs23642734) and one SNP in the STK11 gene ( rs22928814). None of the other SNPs were related to the risk of mammary tumor development. The identification of genetic profiles associated with risk of mammary neoplasia is of great importance, supporting the implementation of specific clinical management strategies in high-risk animals.

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Citations

May 18, 2019·Veterinary and Comparative Oncology·Ana CanadasPatrícia Dias-Pereira
Sep 12, 2019·BMC Veterinary Research·Ana Canadas-SousaPatrícia Dias-Pereira
Sep 1, 2018·Veterinary and Comparative Oncology·Ana CanadasPatrícia Dias-Pereira
Mar 12, 2021·Advanced Drug Delivery Reviews·Lisa A Mestrinho, Ricardo R Santos
Dec 20, 2021·Veterinary and Comparative Oncology·Beatriz Hernández-SuárezAleksandra Pawlak

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Methods Mentioned

BETA
PCR
genotyping
BRIP

Software Mentioned

SPSS
Haploview

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