PMID: 3762124Aug 1, 1986Paper

Canine model for long-term evaluation of prosthetic mitral valves

The Journal of Surgical Research
R W BiancoJ E Foker

Abstract

The evaluation of mechanical prosthetic heart valves would be aided by a more satisfactory animal model. For acute assessment, a variety of animals have been used, but for chronic studies, only larger animals (pigs, calves, baboons) have been employed, creating an expensive model with laboratory management difficulties. Previously, the use of dogs for chronic evaluation has been unsatisfactory because of the frequent occurrence of early sepsis and valve-related thrombotic deaths. We have modified our existing acute dog protocol to produce a successful chronic model. Our model employs perioperative systemic antibiotics, short cardiopulmonary bypass period (range 35-60 min), a minimum of perioperative intravenous lines, postoperative anticoagulation therapy, and strict postoperative antiseptic technique for blood sampling. To evaluate this model, 11 consecutive mongrel dogs underwent mitral valve replacement with either a standard Dacron sewing skirt or a newly devised carbon-coated Teflon sewing skirt No. 23 mm Bjork-Shiley Convexo Concave (CC) prosthetic valve. Nine animals (82%) survived and were evaluated after a predetermined observation interval of either 3 or 6 months for valve function, pannus formation, and possible carb...Continue Reading

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Citations

Sep 30, 2004·The Heart Surgery Forum·Morten SmerupJ Michael Hasenkam
May 16, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·John L SchomburgRichard W Bianco
Feb 12, 1998·The Veterinary Clinics of North America. Small Animal Practice·J M Bright, E Mears
Mar 1, 1987·Journal of Cardiac Surgery·F J Schoen
Mar 17, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Nancy RakowJohn A St Cyr
Mar 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R S SchwartzD R Holmes
Mar 1, 1993·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E IrwinR Bianco
Nov 25, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·C T SalernoR W Bianco
Sep 22, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·D W OuyangR W Bianco
Jun 25, 2019·Frontiers in Cardiovascular Medicine·Benjamin L ZhangFrederick J Schoen
Jan 1, 1992·Avian Pathology : Journal of the W.V.P.A·S M Shane

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