PMID: 4050530Jul 1, 1985Paper

Canine model of contrast medium induced fibrillation

Acta Radiologica: Diagnosis
T W MorrisM Violante

Abstract

The injection of radiocontrast media into coronary arteries will produce a low incidence of ventricular fibrillation. This study establishes the injection duration (or contact time) required to produce fibrillation during right coronary angiography in dogs using a 370 mg I/ml, meglumine/sodium diatrizoate formulation (Renografin 76, Squibb). The mean contact time required to induce fibrillation was 18.8 +/- 5.8 seconds for 66 injections in 47 dogs. Prolonged ischemia of greater than 170 s did not produce either fibrillation or arrhythmias, therefore fibrillation is caused by properties of the media. The contact time was not significantly influenced by test injections and was not significantly different in repeated experiments. The canine contact time model of contrast media induced ventricular fibrillation is reproducible and will facilitate the study of risk factors that increase the possibility of fibrillation.

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Citations

May 1, 1994·European Journal of Radiology·P CipollaC de Haën
Nov 1, 1985·Acta Radiologica: Diagnosis·T W MorrisB Cioffi
Nov 24, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·M F RomanelliJ R Spears
May 24, 2000·The Journal of Veterinary Medical Science·K MisumiH Sakamoto
Mar 1, 1994·The International Journal of Neuroscience·R Sandyk, K Derpapas
Jan 1, 1995·Acta Radiologica. Supplementum·E A JacobsenH Refsum

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