Canine nonresponders to alveolar hypoxic vasoconstriction and quantitative restoration of the response by aspirin I-3

Clinical and Experimental Pharmacology & Physiology
A D Siefkin, G H Parsons

Abstract

Hypoxic pulmonary vasoconstriction is characterized by considerable variability in rate of response (pulmonary vascular resistance [PVR] as a function of time under hypoxia). To further define this response, forty-five closed chest dogs were anaesthetized (pentobarbitone sodium), intubated, and mechanically ventilated. Constant left lower lobar pulmonary artery flow was maintained through a balloon tipped 14F catheter via an extracorporeal pump at a rate to achieve lobar pulmonary artery pressure (Plobar) equal to main pulmonary artery pressure (PPA) and thereafter held constant. Left ventricular end diastolic pressure (PLVED) was measured by left ventricular catheter and lobar pulmonary artery flow rate (Q) by flow meter. Lobar PVR (mmHg/min per 1) was calculated every 15 min. Ventilation with 10% oxygen (O2) separated two groups based on the increase in PVR over time: twenty-two rapid hypoxic responders [HR] (slope= delta PVR/delta min greater than 0.3) and twenty-three slow or nonresponders [NR] (slope less than 0.1). The twenty-three NR were divided into two groups. Ten NR dogs (NR control) had no change in mean PVR (23.9, s.d. = 8.2, to 24.1, s.d. = 9.6) over a mean of 78 min and were used as controls. Thirteen NR dogs (NR...Continue Reading

References

Jan 1, 1979·Respiration; International Review of Thoracic Diseases·D KenteraM Zdravković
Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·R J GryglewskiJ Swies
Jul 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C A HalesJ L Slate
Dec 1, 1978·Canadian Journal of Physiology and Pharmacology·A TuckerR F Grover
Nov 1, 1976·Journal of Applied Physiology·E K WeirR F Grover
Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J M AlexanderK A Jasberg
Oct 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M UngerT K King
Mar 1, 1975·The American Journal of Physiology·A Tucker, J T Reeves
May 1, 1975·Journal of Applied Physiology·J L Benumof, E A Wahrenbrock
Oct 1, 1975·The American Journal of Physiology·P J KadowitzA L Hyman
Dec 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·T TylerS Cassin
Mar 1, 1976·Circulation Research·T C WicksP A Kot
Jan 1, 1973·The American Journal of Physiology·A B Malik, B S Kidd
May 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J Nakano, R B McCloy
Oct 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M L EllsworthJ C Newell
Aug 1, 1983·Respiration Physiology·M S NesarajahL E Farhi
Jan 1, 1983·The American Review of Respiratory Disease·T AhmedA Wanner
Jul 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J G GerberJ T Reeves
Nov 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J T SylvesterR S Frank
Nov 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M A Miller, C A Hales
Sep 1, 1952·The American Journal of Physiology·B M LEWIS, R GORLIN
Apr 1, 1964·The American Journal of Physiology·O G THILENIUSJ F PERKINS

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