Canine pancreaticoduodenal allotransplantation with cystoduodenostomy: an animal model with clinical application

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
D BarrH A Carpenter

Abstract

Most techniques described in animal models of pancreatic transplantation use either segmental or autotransplants. We employ a technique of pancreaticoduodenal allotransplantation in the dog that closely resembles the operation used in humans. The arterial supply of the entire pancreatic graft is preserved by procuring a Carrel patch of aorta encompassing the origin of the celiac and the superior mesenteric arteries. Splenic, inferior pancreaticoduodenal, and superior pancreaticoduodenal arteries remain intact with the graft. Venous drainage is through a short segment of portal vein. A 6-cm cuff of duodenum is taken with the head of the pancreas. Engraftment proceeds by placing the allograft within the peritoneal cavity of the recipient. End-to-side vascular anastomoses are constructed to distal aorta and inferior vena cava. The duodenal cuff is anastomosed to the dome of the bladder for drainage and analysis of exocrine secretions and to provide a port of entry for cystoscopically directed needle biopsy. A total pancreatectomy is performed to induce a state of diabetes. The average operating time is 5 h. Twenty-two dogs have undergone allotransplantation using this technique. Six dogs had no complications and were sacrificed af...Continue Reading

References

Mar 1, 1977·Transplantation Proceedings·G S LeightS A Rosenberg
Feb 1, 1979·American Journal of Surgery·J BissonG W Leadbetter
May 1, 1976·The Journal of Surgical Research·G K KyriakidesJ Miller
Feb 1, 1988·Transplantation·G M AbounaJ S Najarian
Jan 1, 1988·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A R MillerJ D Perkins
Sep 1, 1987·Transplantation·L W Traverso, S MacFarlane
Jan 1, 1967·American Journal of Surgery·F LargiaderR C Lillehei
Sep 1, 1983·American Journal of Surgery·H T Debas, E Passaro
Nov 1, 1983·Archives of Surgery·R MundaJ W Alexander
Sep 1, 1984·The Journal of Surgical Research·L F Cobb, R C Merrell
Mar 1, 1980·American Journal of Surgery·D N Papachristou, J G Fortner

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Citations

Apr 16, 2010·The Cochrane Database of Systematic Reviews·Bruce F WalkerSally Green
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Sidney M RubinsteinMaurits W van Tulder
May 9, 2002·The Journal of Ambulatory Care Management·Monica SmithWilliam Meeker
May 4, 2000·Journal of Telemedicine and Telecare·L H SchoppO C Merveille

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