Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease

Vaccine
T D YuleR Fanton

Abstract

Inflammatory changes following infection are central to the clinical manifestation of disease. However, information regarding such changes in animal disease is limited. In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. These parameters correlated with conventional assessment of clinical disease in a vaccine efficacy study. Seropositive (CPV-2) 6-week-old puppies given three doses of a CPV-2 containing vaccine developed significant antibody titers and remained healthy after experimental infection with CPV-2b. Unvaccinated controls developed clinical signs and shed virus. Importantly, acute phase proteins became elevated, and lymphopenia, neutropenia and modulation of neutrophil-CD4 were detected in controls but not in vaccinates.

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Citations

Jul 17, 2008·Veterinary Research Communications·M YukiK Takase
Oct 26, 2013·The Veterinary Record·K CrawfordA G Gow
Jul 14, 2010·The Veterinary Journal·P D Eckersall, R Bell
Jun 13, 2006·Veterinary Microbiology·Uwe Truyen
Jul 16, 2010·The Journal of Small Animal Practice·M KocaturkZ Yilmaz
Jul 22, 2014·The Journal of Small Animal Practice·M KocaturkJ J Ceron
Sep 18, 2014·ACS Applied Materials & Interfaces·Tara D SutherlandTsunenori Kameda
Sep 8, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Charles HongJeremiah T Saliki
Mar 28, 2019·Proceedings. Biological Sciences·Abdelkader BehdennaMafalda Viana
Dec 28, 2007·Clinical and Vaccine Immunology : CVI·Alessandra CavalliCanio Buonavoglia
Feb 24, 2001·The Veterinary Record·P D EckersallJ L Fitzpatrick
May 12, 2009·The Veterinary Record·N DecaroC Buonavoglia
Apr 27, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Michèle BergmannKatrin Hartmann

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