Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
S G ShapiroMatthew Breen

Abstract

Urothelial carcinoma (UC), also referred to as transitional cell carcinoma (TCC), is the most common bladder malignancy in both human and canine populations. In human UC, numerous studies have demonstrated the prevalence of chromosomal imbalances. Although the histopathology of the disease is similar in both species, studies evaluating the genomic profile of canine UC are lacking, limiting the discovery of key comparative molecular markers associated with driving UC pathogenesis. In the present study, we evaluated 31 primary canine UC biopsies by oligonucleotide array comparative genomic hybridization (oaCGH). Results highlighted the presence of three highly recurrent numerical aberrations: gain of dog chromosome (CFA) 13 and 36 and loss of CFA 19. Regional gains of CFA 13 and 36 were present in 97 % and 84 % of cases, respectively, and losses on CFA 19 were present in 77 % of cases. Fluorescence in situ hybridization (FISH), using targeted bacterial artificial chromosome (BAC) clones and custom Agilent SureFISH probes, was performed to detect and quantify these regions in paraffin-embedded biopsy sections and urine-derived urothelial cells. The data indicate that these three aberrations are potentially diagnostic of UC. Compar...Continue Reading

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Citations

May 11, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·R OmeirA M Lewis
Sep 25, 2015·Canine Genetics and Epidemiology·S G ShapiroMatthew Breen
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Joshua D Schiffman, Matthew Breen
Jan 5, 2017·Genes, Chromosomes & Cancer·Stephen A RamseyShay Bracha
Nov 27, 2018·ILAR Journal·Nana H OvergaardGregers Jungersen
Jun 4, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sarah C RoodeMatthew Breen
Apr 24, 2019·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Katherine KennedyMatthew Breen
Jan 4, 2016·Veterinary Sciences·Katherine KennedyMatthew Breen
Aug 24, 2015·Veterinary Sciences·Hiroyuki Mochizuki, Matthew Breen
Jan 7, 2017·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Hiroyuki MochizukiMatthew Breen
Sep 17, 2020·Nature Reviews. Cancer·Amy K LeBlanc, Christina N Mazcko
Mar 12, 2021·Advanced Drug Delivery Reviews·Lisa A Mestrinho, Ricardo R Santos
May 23, 2021·Veterinary and Comparative Oncology·Kathryn E CroniseDawn L Duval

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