Cannabichromene is a cannabinoid CB2 receptor agonist

British Journal of Pharmacology
Michael Philip UdohMark Connor

Abstract

Cannabichromene (CBC) is one of the most abundant phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti-inflammatory effects and potentiates some effects of Δ9 -tetrahydrocannabinol in vivo. How CBC exerts these effects is poorly defined and there is little information about its efficacy at cannabinoid receptors. We sought to determine the functional activity of CBC at cannabinoid CB1 and CB2 receptors. AtT20 cells stably expressing haemagglutinin-tagged human CB1 and CB2 receptors were used. Assays of cellular membrane potential and loss of cell surface receptors were performed. CBC activated CB2 but not CB1 receptors to produce hyperpolarization of AtT20 cells. This activation was inhibited by a CB2 receptor antagonist AM630, and sensitive to Pertussis toxin. Application of CBC reduced activation of CB2 , but not CB1 , receptors by subsequent co-application of CP55,940, an efficacious CB1 and CB2 receptor agonist. Continuous CBC application induced loss of cell surface CB2 receptors and desensitization of the CB2 receptor-induced hyperpolarization. CBC is a selective CB2 receptor agonist displaying higher efficacy than tetrahydrocannabinol in hyperpolarizing AtT20 cells. CBC can also recruit CB2 receptor r...Continue Reading

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Citations

Mar 11, 2020·Annual Review of Plant Biology·I KovalchukT F Sharbel
Jul 18, 2020·Journal of Dietary Supplements·Elnaz Karimian AzariAnnalouise O'Connor
Jul 2, 2020·British Journal of Pharmacology·Nicole L StoneSaoirse E O'Sullivan
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Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karim S LadhaHance Clarke
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Jan 21, 2021·International Journal of Molecular Sciences·Anna StasiłowiczJudyta Cielecka-Piontek
Apr 7, 2021·Pharmacology Research & Perspectives·Laureano SchofsSergio F Sánchez Bruni
Apr 15, 2021·Planta medica·Giulia MartinelliEnrico Sangiovanni
Jun 6, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rebecca FerrisiFrancesca Gado
Jul 30, 2021·ImmunoTargets and Therapy·Valeria GiorgiPiercarlo Sarzi-Puttini
Jun 9, 2021·Genome Biology and Evolution·Robin van Velzen, M Eric Schranz
Sep 20, 2021·Neuroscience and Biobehavioral Reviews·Natalie Prowse, Shawn Hayley

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