Cannabidiol (CBD) Consumption and Perceived Impact on Extrahepatic Symptoms in Patients with Autoimmune Hepatitis

Digestive Diseases and Sciences
Karan MathurCraig Lammert

Abstract

Utilization and safety of cannabidiol (CBD) in patients with autoimmune hepatitis (AIH) are currently unknown. We aimed to identify the frequency of CBD use, impact on symptoms, and safety profile. An invitation to complete a CBD-specific questionnaire was posted every other day to well-established autoimmune hepatitis Facebook communities (combined membership of 2600 individuals) during a 10-day study period. Age ≥ 18 years and an AIH diagnosis by a physician were the eligibility criteria for participation in the survey. In total, 371 AIH patients (median age 49 years, 32% reported advanced fibrosis) completed the questionnaire. Respondents were 91% women, 89% Caucasian, and 89% from North America. Ninety-three (25%) respondents were ever CBD users, with 55 of them (15% of the survey responders) identified as current users. Among ever users, 45.7% reported their treating doctors were aware of their CBD use. The most common reason cited for CBD use was pain (68%), poor sleep (62%), and fatigue (38%). Most respondents using CBD for these symptoms reported a significant improvement in pain (82%), sleep (87%), and fatigue (61%). In ever CBD users, 17.3% were able to stop a prescription medication because of CBD use: pain medicatio...Continue Reading

References

Mar 6, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Simone M van der PlasSolko W Schalm
Aug 23, 2007·Chemistry & Biodiversity·Marilyn A Huestis
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Felicity L Bishop, G T Lewith
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P MannsUNKNOWN American Association for the Study of Liver Diseases
Jun 19, 2013·Lancet·Michael A HeneghanMaria Serena Longhi
Nov 19, 2013·Journal of Hepatology·Christoph SchrammMatthias Rose
Apr 16, 2014·Pediatrics·Kurt R SchumacherMark W Russell
Jun 24, 2015·JAMA : the Journal of the American Medical Association·Penny F WhitingJos Kleijnen
Sep 6, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Aug 2, 2016·Journal of Clinical Gastroenterology·Jacqueline B HensonAndrew J Muir
Sep 14, 2016·Frontiers in Pharmacology·Michelle R PeaceAlphonse Poklis
Feb 12, 2017·Epilepsy & Behavior : E&B·Brooke K O'ConnellOrrin Devinsky
Mar 10, 2017·Expert Review of Gastroenterology & Hepatology·Carina HasenoehrlRudolf Schicho
Apr 24, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anand KulanthaivelCraig Lammert
Oct 31, 2017·Expert Opinion on Drug Safety·Carola RongRoger S McIntyre
Nov 9, 2017·JAMA : the Journal of the American Medical Association·Marcel O Bonn-MillerRyan Vandrey
Jan 20, 2018·Journal of Medical Internet Research·Megan ComerfordCraig Steven Lammert
Apr 18, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lin Lee WongUNKNOWN UK-AIH Consortium
Sep 1, 2018·European Journal of Gastroenterology & Hepatology·Hemant GoyalRajiv Chhabra
Sep 12, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Maciej K JanikPiotr Milkiewicz
Oct 5, 2018·PloS One·Atsushi TakahashiUNKNOWN Japan AIH Study Group
Apr 24, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Abbie D LeinoRita R Alloway

❮ Previous
Next ❯

Citations

Oct 21, 2020·Pharmacotherapy·Sarah D Pennypacker, E Alfonso Romero-Sandoval
Jul 25, 2021·International Journal of Molecular Sciences·Bryan Latrell HollomanPrakash Nagarkatti
Jul 29, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Vahin VuppalanchiCraig Lammert

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Cannabis and Cannabinoid Research
Jamie Corroon, Joy A Phillips
British Journal of Clinical Pharmacology
Christopher P StanleySaoirse E O'Sullivan
BioRxiv : the Preprint Server for Biology
Mehrak Javadi-PaydarMichael A Taffe
© 2021 Meta ULC. All rights reserved