Cannabidiol in medical marijuana: Research vistas and potential opportunities

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Carola RongRoger S McIntyre

Abstract

The high and increasing prevalence of medical marijuana consumption in the general population invites the need for quality evidence regarding its safety and efficacy. Herein, we synthesize extant literature pertaining to the phytocannabinoid cannabidiol (CBD) and its brain effects. The principle phytocannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) and CBD are the major pharmacologically active cannabinoids. The effect of CBD on brain systems as well as on phenomenological measures (e.g. cognitive function) are distinct and in many cases opposite to that of Δ9-THC. Cannabidiol is without euphoriant properties, and exerts antipsychotic, anxiolytic, anti-seizure, as well as anti-inflammatory properties. It is essential to parcellate phytocannabinoids into their constituent moieties as the most abundant cannabinoid have differential effects on physiologic systems in psychopathology measures. Disparate findings and reports related to effects of cannabis consumption reflect differential relative concentration of Δ9-THC and CBD. Existing literature, notwithstanding its deficiencies, provides empirical support for the hypothesis that CBD may exert beneficial effects on brain effector systems/substrates subserving domain-based phenomenolog...Continue Reading

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Citations

Dec 6, 2017·Postgraduate Medicine·Devina Singh, Steven Lippmann
Oct 31, 2017·Expert Opinion on Drug Safety·Carola RongRoger S McIntyre
Jan 16, 2019·CNS Spectrums·Roger S McIntyreStephen M Stahl
Jan 19, 2018·Journal of Epilepsy Research·Emilio Perucca
Aug 1, 2019·Brain : a Journal of Neurology·Anthony FeinsteinRichard W Staines
Aug 27, 2019·Channels·C JansenH Turner
Nov 18, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Andre F CarvalhoAi Koyanagi
Dec 29, 2019·Antioxidants·Sinemyiz AtalayElzbieta Skrzydlewska
Dec 5, 2019·British Journal of Pharmacology·Elizabeth M WilliamsonAngelo A Izzo
Feb 26, 2020·Substance Use & Misuse·Meghann WheelerHanadi Hamadi
Mar 1, 2019·SAGE Open Medical Case Reports·Josep Sulé-SusoApurna Jegannathen
Jul 30, 2020·International Journal of Molecular Sciences·Mikołaj MizeraJudyta Cielecka-Piontek
Jun 8, 2018·Neurochemical Research·Eric Murillo-RodríguezHenning Budde
Aug 3, 2019·Drugs·Valentina Franco, Emilio Perucca
Mar 21, 2020·International Journal of Environmental Research and Public Health·Farzad JalilianSerge Brand
Sep 29, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Gioacchino CalapaiFabio Firenzuoli
Jul 14, 2020·Cannabis and Cannabinoid Research·Reilly R KayserH Blair Simpson
May 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Radmila PavlovicAnnamaria Giorgi
Feb 23, 2019·Journal of Palliative Medicine·April Christensen, Jennifer Pruskowski
Oct 31, 2019·International Journal of Environmental Research and Public Health·Nathan T Pearson, James H Berry
Nov 17, 2020·Neurodegenerative Disease Management·Ganesh GopalakrishnaGurmehr Kaur
Aug 15, 2019·Neurotoxicology·Stefania BonaccorsoFabrizio Schifano
Dec 13, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Madelyne A BisbyKathryn D Baker
Jan 21, 2021·International Journal of Molecular Sciences·Anna StasiłowiczJudyta Cielecka-Piontek
Mar 5, 2021·International Medical Case Reports Journal·Mark Mohan KaggwaScholastic Ashaba
Oct 10, 2020·Neuropharmacology·Gabriella MarucciFrancesco Amenta
Apr 18, 2021·Current Psychiatry Reports·Julia D BucknerElizabeth M Lewis
Jan 31, 2018·The Journal of the American Osteopathic Association·Jeramy Peters, Joseph Chien
Apr 25, 2021·Journal of Cannabis Research·Juan L RodriguezJ Jordan Steel
May 1, 2021·Biomolecules·Fei Wang, Gabriele Multhoff
May 23, 2021·Drug Testing and Analysis·Keeley DunnSophie Turfus
Dec 23, 2017·Chemical Research in Toxicology·James T WilsonJoseph E Deweese
Apr 4, 2019·Medical Cannabis and Cannabinoids·Yukako NakanoHitoshi Sato
Nov 26, 2021·Frontiers in Chemistry·Panyong ZhuBo Yang

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