Cannabidiol injected into the bed nucleus of the stria terminalis modulates baroreflex activity through 5-HT1A receptors

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Fernando H F AlvesLeonardo B M Resstel

Abstract

Cannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis sativa plant that inhibits behavioral and cardiovascular responses to aversive situations, facilitating 5-HT1A-mediated neurotransmission. Previous results from our group suggest that the bed nucleus of the stria terminalis (BNST) may be involved in CBD's anti-aversive effects. To investigate whether the cardiovascular effects of the CBD could involve a direct drug effect on the BNST, we evaluated the effects of CBD microinjection into this structure on baroreflex activity. We also verified whether these effects were mediated by the activation of 5-HT(1A) receptors. Bilateral microinjection of CBD (60 nmol/100 nL) into the BNST increased the bradycardiac response to arterial pressure increases. However, no changes were observed in tachycardiac responses evoked by arterial pressure decreases. Pretreatment of the BNST with the selective 5-HT(1A) receptor antagonist WAY100635 (0.37 nmol/100 nL) prevented CBD effects on the baroreflex activity. Moreover, microinjection of the 5-HT(1A) receptor agonist 8-OH-DPAT (4 nmol/100 nL) caused effects that were similar to those observed after the microinjection of CBD, which were also blocked by pretreatment with WAY10063...Continue Reading

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Oct 9, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Felipe V GomesCarlos C Crestani
Oct 26, 2011·British Journal of Pharmacology·Barbara MalinowskaEberhard Schlicker
Aug 14, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yasmin L HurdDidier Jutras-Aswad
Aug 13, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Clementino Ibeas BihBenjamin J Whalley
Jul 21, 2011·Pharmacology, Biochemistry, and Behavior·Erica M GranjeiroLeonardo B M Resstel
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Jun 23, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah E Daniel, Donald G Rainnie
Nov 17, 2017·Pflügers Archiv : European journal of physiology·Nilson Carlos Ferreira-JuniorLeonardo Barbosa Moraes Resstel
Mar 14, 2017·Frontiers in Pharmacology·Salahaden R SultanSaoirse E O'Sullivan
Nov 8, 2017·Frontiers in Pharmacology·Eva Martínez-PinillaRafael Franco
Sep 18, 2020·International Journal of Molecular Sciences·Aleksandra Kicman, Marek Toczek
Nov 23, 2020·Psychopharmacology·Stevie C BritchSharon L Walsh

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