Cannabidiol: pharmacology and therapeutic targets.

Psychopharmacology
Stevie C BritchSharon L Walsh

Abstract

Cannabidiol (CBD) products lacking regulatory approval are being used to self-treat a myriad of conditions and for their unsubstantiated health benefits. The scientific evidence supporting these claims largely arises not from controlled clinical trials, but from the recognition that CBD has numerous biological targets. Yet, CBD is commonly consumed and often in over-the-counter products that are unapproved and of unknown composition. Epidiolex® is the only product that has undergone rigorous pharmacokinetic assessment and testing in clinical trials; it was approved as a non-scheduled drug by the U.S. Food and Drug Administration for the treatment of intractable childhood-onset seizures. However, studies investigating CBD for other medical conditions are limited in number and often lack the scientific rigor, controls, or sample sizes required to draw clinically meaningful conclusions. Although Epidiolex® is safe for human consumption, recent changes in regulation of commercially available CBD products have resulted in limited quality control and products marketed with unknown CBD bioavailability. Even scientifically rigorous studies have used different sources of CBD and different suspension vehicles for administration, making i...Continue Reading

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Citations

Mar 2, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Mar 7, 2021·International Journal of Molecular Sciences·Barbara MalinowskaEberhard Schlicker
Apr 17, 2021·Expert Review of Clinical Pharmacology·Gabor XantusPeter Kanizsai
Apr 23, 2021·Epilepsy & Behavior : E&B·Willian Lazarini-LopesNorberto Garcia-Cairasco
Jul 14, 2021·Expert Opinion on Drug Delivery·Ízola Morais de Medeiros RamalhoEryvaldo Socrates Tabosa do Egito

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Methods Mentioned

BETA
pharmacotherapies
amputation
pharmacotherapy

Software Mentioned

Epidiolex®

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