PMID: 20124735Feb 4, 2010Paper

Cannabinoid 1 receptor blockade reduces atherosclerosis with enhances reverse cholesterol transport

Journal of Atherosclerosis and Thrombosis
Koichi SugamuraHisao Ogawa

Abstract

A recent clinical study using coronary intravascular ultrasound showed that rimonabant, a cannabinoid 1 (CB1) receptor antagonist, significantly reduced total atheroma volume, suggesting that CB1 receptor blockade could be beneficial in anti-atherogenic therapy. The reverse cholesterol transport (RCT) system plays important roles in atherogenesis. We investigated whether CB1 receptor blockade could modulate atherogenesis in mice. Oral administration of rimonabant (8 mg/kg/day) to apolipoprotein E-deficient mice for 3 months significantly reduced the relative area of atherosclerotic lesions in the aorta (vehicle; 12.6+/-4.0% vs. rimonabant; 9.7+/-2.3, n=12 each, p<0.05) with an increase in serum adiponectin levels (15.6+/-2.3 microg/mL vs. 12.2+/-2.1, n=12 each, p<0.001), without affecting body weight or serum cholesterol levels. Rimonabant tended to increase serum high-density lipoprotein cholesterol (HDL-C) (p=0.05). The relative area of atherosclerotic lesions in the aorta correlated inversely with serum HDL-C levels (r=-0.45, n=24, p<0.05). Rimonabant upregulated the mRNA expression levels of various components of the RCT system on THP-1 cell-derived macrophages (scavenger receptor B1: 1.15+/-0.12 fold, n=6; p<0.05, ATP-bind...Continue Reading

References

Dec 20, 2002·Nature·Peter Libby
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nan WangAlan R Tall
Jan 12, 2005·Diabetes, Obesity & Metabolism·B PoirierJ-M Herbert
Nov 18, 2005·The New England Journal of Medicine·Jean-Pierre DesprésUNKNOWN Rimonabant in Obesity-Lipids Study Group
Feb 16, 2006·JAMA : the Journal of the American Medical Association·F Xavier Pi-SunyerUNKNOWN RIO-North America Study Group
May 23, 2006·Nature Medicine·Fatima Teixeira-ClercSophie Lotersztajn
Aug 24, 2006·The New England Journal of Medicine·Kenneth F AdamsMichael F Leitzmann
Dec 6, 2006·Journal of Atherosclerosis and Thrombosis·Hiroshi HayashiKyoko Miyasaka
Mar 9, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Noriyuki Ouchi, Kenneth Walsh
Dec 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Xinwen WangChangyi Chen
Apr 5, 2008·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN STRADIVARIUS Investigators
Apr 17, 2008·Circulation·Sei NakataNobuyuki Yanagihara
Apr 29, 2008·Atherosclerosis·Paul E Szmitko, Subodh Verma
Aug 16, 2008·Biochemical and Biophysical Research Communications·Kazumi Tsubakio-YamamotoShizuya Yamashita
Oct 11, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Frédérique Dol-GleizesFrançoise Bono
Dec 30, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésUNKNOWN ADAGIO-Lipids Investigators
Feb 18, 2009·Circulation·Fiona C McGillicuddyMuredach P Reilly

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Citations

Jun 1, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rodrigo GuabirabaMauro M Teixeira
May 5, 2011·PloS One·Florian WilleckeAndreas Zirlik
Dec 25, 2015·Toxics·Anberitha T Matthews, Matthew K Ross
Sep 13, 2011·International Journal of Cardiology·Aristeidis G VaiopoulosMichael Koutsilieris
Sep 15, 2012·Journal of Atherosclerosis and Thrombosis·Paulin Beya Wa Bitadi MutomboKuninori Shiwaku
Oct 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tony JourdanPascal Degrace
Jan 27, 2012·Clinical Cardiology·Sandeep SinglaJawahar L Mehta
Jul 9, 2010·Biochemical and Biophysical Research Communications·Courtney Netherland, Douglas P Thewke
Sep 8, 2015·Arthritis Research & Therapy·Torsten Lowin, Rainer H Straub
Jun 2, 2016·Open Biology·Christopher Lipina, Harinder S Hundal
Mar 7, 2017·Canadian Journal of Physiology and Pharmacology·Yan Lu, Hope D Anderson
Jan 13, 2018·American Journal of Therapeutics·Sushilkumar S GuptaStephan L Kamholz
Oct 28, 2016·American Journal of Physiology. Cell Physiology·Anberitha T MatthewsMatthew K Ross
Apr 23, 2020·International Journal of Molecular Sciences·Adam StasiulewiczAnd Joanna I Sulkowska
May 1, 2018·Proceedings·Brooke MillsCarlos E Velasco

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