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Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy

Neuroscience Letters

Nov 18, 2006

Laxmikant S DeshpandeRobert J DeLorenzo

Abstract

Status epilepticus (SE) is a major medical emergency associated with a significant morbidity and mortality. Little is known about the mechanisms that terminate seizure activity and prevent the development of status epilepticus. Cannabinoids possess anticonvulsant properties and the endo...read more

Mentioned in this Paper

Cannabinoids
Pyrazoles
Naphthalenes
Morbidity Aspects
(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonate
Anticonvulsants
Acomplia
Epilepsy
Neurons
Synaptic Transmission
1
5
65
Paper Details
References
  • References15
  • Citations43
12
  • References15
  • Citations43
12345

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European Journal of Pharmacology

Endocannabinoids block status epilepticus in cultured hippocampal neurons

European Journal of PharmacologyDecember 19, 2006
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Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy

Neuroscience Letters

Nov 18, 2006

Laxmikant S DeshpandeRobert J DeLorenzo

PMID: 17110038

DOI: 10.1016/j.neulet.2006.09.046

Abstract

Status epilepticus (SE) is a major medical emergency associated with a significant morbidity and mortality. Little is known about the mechanisms that terminate seizure activity and prevent the development of status epilepticus. Cannabinoids possess anticonvulsant properties and the endo...read more

Mentioned in this Paper

Cannabinoids
Pyrazoles
Naphthalenes
Morbidity Aspects
(2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonate
Anticonvulsants
Acomplia
Epilepsy
Neurons
Synaptic Transmission
1
5
65

Feeds With Similar Papers

Neuronal Identity

Neuronal identity is important for defining the end result of stem cell differentiation through neuronal developmentor for regenerative medicine. This could involved transcription factors used to drive induce pluripotent stem cells towards the neuronal lineage. Discover the latest research on Neuronal Identity here.

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Related Papers

European Journal of Pharmacology

Endocannabinoids block status epilepticus in cultured hippocampal neurons

European Journal of PharmacologyDecember 19, 2006
Laxmikant S DeshpandeRobert J DeLorenzo
Paper Details
References
  • References15
  • Citations43
12
  • References15
  • Citations43
12345

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