Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma

Clinical Biochemistry
Gorka LarrinagaJose I López

Abstract

To analyze the mRNA and protein expression of cannabinoid receptors CB1 and CB2 in chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO). Fresh and formalin-fixed tissue samples of ChRCC and RO were analyzed by using real-time quantitative RT-PCR and immunohistochemical techniques (n=40). Quantitative RT-PCR analysis showed that CB1 mRNA was underexpressed by 12-fold in ChRCC and had a variable expression in RO. CB1 protein showed intense positive immunostaining in both neoplasms. Both CB2 mRNA and protein were not expressed in tumor and non tumor renal tissue. This distinct immunoprofile may eventually be used as an additional tool with practical interest in the differential diagnosis of renal tumors.

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Citations

Oct 21, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianfeng WangJin Zhang
Oct 22, 2013·Virchows Archiv : an International Journal of Pathology·José I LópezRegina Tardanico
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May 31, 2019·Frontiers in Pharmacology·Robert RamerBurkhard Hinz
Oct 11, 2017·Journal of Cancer Research and Clinical Oncology·Jianfeng WangJin Zhang

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