Cannabinoid Profiling of Hemp Seed Oil by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

Frontiers in Plant Science
Cinzia CittiGiuseppe Cannazza

Abstract

Hemp seed oil is well known for its nutraceutical, cosmetic and pharmaceutical properties due to a perfectly balanced content of omega 3 and omega 6 polyunsaturated fatty acids. Its importance for human health is reflected by the success on the market of organic goods in recent years. However, it is of utmost importance to consider that its healthy properties are strictly related to its chemical composition, which varies depending not only on the manufacturing method, but also on the hemp variety employed. In the present work, we analyzed the chemical profile of ten commercially available organic hemp seed oils. Their cannabinoid profile was evaluated by a liquid chromatography method coupled to high-resolution mass spectrometry. Besides tetrahydrocannabinol and cannabidiol, other 30 cannabinoids were identified for the first time in hemp seed oil. The results obtained were processed according to an untargeted metabolomics approach. The multivariate statistical analysis showed highly significant differences in the chemical composition and, in particular, in the cannabinoid content of the hemp oils under investigation.

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Aug 24, 2018·Journal of Pharmaceutical and Biomedical Analysis·Cinzia CittiGiuseppe Cannazza

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Citations

Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alberto RamellaCarlo Grizzetti
Apr 15, 2020·Analytical and Bioanalytical Chemistry·Cinzia CittiGiuseppe Cannazza
Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara PalmieriManuel Sergi
Sep 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·H P Vasantha RupasingheValtcho D Zheljazkov
Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marialuisa FormatoSeverina Pacifico
Aug 23, 2020·Foods·Simona PiccolellaSeverina Pacifico
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luana IzzoAlberto Ritieni
Dec 8, 2020·The New Phytologist·Bhavna HurgobinMathew G Lewsey
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·William LeonardZhongxiang Fang
Jan 16, 2021·Journal of the American Animal Hospital Association·Sebastian MejiaStephanie McGrath
Feb 23, 2021·Cannabis and Cannabinoid Research·Cinzia CittiGiuseppe Cannazza
Mar 7, 2021·International Journal of Molecular Sciences·Kaitlyn Blatt-Janmaat, Yang Qu
May 15, 2021·Journal of Pharmaceutical and Biomedical Analysis·Simona PiccolellaSeverina Pacifico
Jan 11, 2022·Journal of Natural Products·Richard B van BreemenFikadu G Tafesse

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Methods Mentioned

BETA
PCA

Software Mentioned

XCMS Online platform
Qual Browser
XCMS Online
MetaboAnalyst
Xcalibur
MSA
mzCloud

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