Cannabinoid receptor-1 antagonism: a new perspective on treating a murine schistosomal liver fibrosis model

Memórias do Instituto Oswaldo Cruz
Yasmine Amr IssaRasha Fadly Mady

Abstract

Formation of schistosomal granulomata surrounding the ova can result in schistosomiasis-associated liver fibrosis (SSLF). The current standard of treatment is praziquantel (PZQ), which cannot effectively reverse SSLF. The role of the cannabinoid (CB) receptor family in liver fibrosis has recently been highlighted. This study aimed to assess the therapeutic effect of CB1 receptor antagonism in reversing SSLF in a murine model of Schistosoma mansoni infection. One hundred male Swiss albino mice were divided equally into five groups: healthy uninfected control (group I), infected control (group II), PZQ treated (group III), rimonabant (RIM) (SR141716, a CB1 receptor antagonist)-treated (group IV) and group V was treated with combined PZQ and RIM. Liver sections were obtained for histopathological examination, alpha-1 smooth muscle actin (α-SMA) immunostaining and assessment of CB1 receptor expression using real-time polymerase chain reaction (RT-PCR). The most effective reduction in fibrotic marker levels and granuloma load was achieved by combined treatment with PZQ+RIM (group V): CB1 receptor expression (H = 26.612, p < 0.001), number of α-SMA-positive cells (F = 57.086, p < 0.001), % hepatic portal fibrosis (F = 42.849, p < 0.0...Continue Reading

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Citations

Aug 25, 2020·Journal of Clinical and Translational Hepatology·Yue Chang, Hai Li
Jan 12, 2020·Pharmacology & Therapeutics·Resat CinarGeorge Kunos

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Methods Mentioned

BETA
biopsy
SMA
anti-SMA
biopsies

Software Mentioned

SPSS

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