Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes

Molecular Immunology
Sharmistha GhoshRamesh K Ganju

Abstract

Cannabinoids have been shown to influence the immune system. However, their immunomodulatory effects have not been extensively studied. In this investigation, we have observed that both primary and Jurkat T cells express a functional cannabinoid receptor 2 (CB(2)). Furthermore, both the synthetic cannabinoids CP55,940 and WIN55,212-2, as well as the CB(2)-selective agonist JWH-015, caused a significant inhibition of the chemokine CXCL12-induced and CXCR4-mediated chemotaxis of Jurkat T cells, as well as their transendothelial migration. Involvement of the CB(2) receptor was further confirmed by partial reversal of the inhibition using the CB(2)-specific antagonist, AM630. Similarly, CP55,940 and JWH-015 inhibited the CXCL12-induced chemotaxis of primary CD4(+) and CD8(+) T lymphocytes. Further investigation of signaling studies to delineate the mechanism of inhibition revealed that cannabinoids enhance CXCL12-induced p44/42 MAP kinase activity. However, enhanced MAP kinase activity was not responsible for the inhibition of chemotaxis. This suggests that cannabinoids differentially regulate CXCR4-mediated migration and MAP kinase activation in T cells. Cannabinoids were also found to downregulate the PMA-enhanced enzyme activity...Continue Reading

Citations

Feb 6, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Erinn S RabornGuy A Cabral
Jul 5, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rebecca Hartzell RobinsonToby K Eisenstein
Jan 21, 2009·Expert Reviews in Molecular Medicine·Guy A Cabral, LaToya Griffin-Thomas
Nov 4, 2011·Cell Death & Disease·A M WasikB Sander
Sep 9, 2006·Current Opinion in Lipidology·Sabine Steffens, Francois Mach
Nov 16, 2010·Molecular Cancer Research : MCR·Mahandranauth A ChetramCimona V Hinton
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Takashi TanikawaYasuyuki Imai
Mar 2, 2010·Future Medicinal Chemistry·Prakash NagarkattiMitzi Nagarkatti
Feb 11, 2014·Brain, Behavior, and Immunity·Paula Suárez-PinillaBenedicto Crespo-Facorro
Jun 16, 2014·Neuromolecular Medicine·Esmée Vendel, Elizabeth C M de Lange
Jul 18, 2006·Biochemical and Biophysical Research Communications·Masashi KohnoMasaki Yasukawa
Apr 10, 2009·Seminars in Immunopathology·Pál Pacher, Sabine Steffens
Sep 1, 2012·Translational Stroke Research·Ming ZhangRonald F Tuma
Apr 9, 2008·Molecular and Cellular Endocrinology·Tibor HarkanyJan Mulder
Sep 11, 2007·Acta Neurologica Scandinavica·C M Poser, V V Brinar
Oct 16, 2007·British Journal of Pharmacology·C BenitoJ Romero
Nov 6, 2007·British Journal of Pharmacology·A M Miller, N Stella
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Bo ShenXin-En Huang
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathryn A SeelyLiana Fattore
May 20, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rebecca H RobinsonToby K Eisenstein
Apr 17, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Toby K Eisenstein, Joseph J Meissler
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·Caroline TurcotteNicolas Flamand
Aug 15, 2014·BMC Musculoskeletal Disorders·Shin FukudaToshihiro Nanki
Jun 17, 2008·Toxicology and Applied Pharmacology·Theodore SarafianMichael D Roth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.