Cannabinoid receptor-mediated inhibition of dopamine release in the retina.

Naunyn-Schmiedeberg's Archives of Pharmacology
E SchlickerM Göthert

Abstract

The possible occurrence of cannabinoid (CB) receptors was studied on superfused guinea-pig retinal discs preincubated with [3H]dopamine or [3H]noradrenaline. Tritium overflow was evoked either electrically (3 Hz) or by re-introduction of Ca2+ 1.3 mM after superfusion with Ca(2+)-free medium containing K+ 30 mM. The accumulation of [3H]dopamine ([3H]DA) and [3H]noradrenaline ([3H]NA) was inhibited by the selective inhibitor of the neuronal dopamine transporter GBR-12909 (pIC50% 7.29 and 7.41, respectively) but not by the selective inhibitor of the neuronal noradrenaline transporter desipramine (1 microM). The electrically or Ca(2+)-evoked tritium overflow in retinal discs preincubated with [3H]DA or [3H]NA was reduced by the CB receptor agonists CP-55,940 and WIN 55,212-2 (pIC50% in discs preincubated with [3H]NA, electrical stimulation: 7.03 and 6.70, respectively) but not affected by the inactive S(-)enantiomer of the latter, WIN 55,212-3 (up to 10 microM). The concentration-response curve of WIN 55,212-2 was shifted to the right by the CB1 receptor antagonist SR 141716 (apparent pA2: 8.29) which, by itself, increased the evoked overflow. The facilitatory effect of SR 141716 was not affected by GBR-12909 and the dopamine recep...Continue Reading

References

Nov 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
Jul 1, 1989·Physiological Reviews·K StarkeH Kilbinger
Mar 1, 1988·Trends in Pharmacological Sciences·J Z Nowak
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel
Sep 10, 1984·Life Sciences·M Hadjiconstantinou, N H Neff
Aug 17, 1984·European Journal of Pharmacology·R E Heikkila, L Manzino
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·A C Howlett
Aug 1, 1996·British Journal of Pharmacology·R G PertweeA A Coutts

❮ Previous
Next ❯

Citations

Dec 14, 1999·The Journal of Comparative Neurology·S YazullaD G Deutsch
Oct 1, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·T SchultheissE Schlicker
Dec 28, 1999·European Journal of Pharmacology·A A IzzoF Capasso
Aug 17, 2002·Pharmacology & Therapeutics·Tomi JärvinenKrista Laine
Nov 8, 2001·Trends in Pharmacological Sciences·E Schlicker, M Kathmann
Feb 13, 2001·Progress in Neurobiology·R G Pertwee
Jan 29, 2003·Current Opinion in Pharmacology·James Doherty, Raymond Dingledine
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·M Costigan, C J Woolf
Apr 28, 2006·Visual Neuroscience·Mieke L StruikMaarten Kamermans
Apr 13, 2000·The European Journal of Neuroscience·A PorcellaL Pani
Jan 21, 2014·Psychopharmacology·Claire WhiteMark Edwards
Jul 26, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Hester van DiepenMartin C Michel
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·A StraikerG Maguire
Feb 18, 2016·Neural Plasticity·Thomas SchwitzerVincent Laprevote
Feb 18, 2016·Neural Plasticity·Despina KokonaKyriaki Thermos
Feb 4, 2016·Neural Plasticity·Jean-François BouchardWilliam John Redmond
May 20, 2009·Neurobiology of Learning and Memory·Mohammad NasehiMohammad Reza Zarrindast
Aug 30, 2008·Progress in Retinal and Eye Research·Stephen Yazulla
Oct 13, 2007·European Journal of Pharmacology·Thorsten Lau, Patrick Schloss
Jul 24, 2010·The Journal of Comparative Neurology·Sherry Shu-Jung HuAlex Straiker
Apr 14, 2016·Neural Plasticity·Joseph BouskilaMaurice Ptito
Mar 6, 2012·Human Psychopharmacology·Elizabeth MurrayJohn Brown
Apr 13, 2005·Biochemical and Biophysical Research Communications·June ChenVincenzo Di Marzo
Dec 9, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Thomas SchwitzerVincent Laprevote
Dec 13, 2012·Neurobiology of Learning and Memory·Behnam YousefiMohammad Reza Zarrindast
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R G Pertwee, R A Ross
Oct 19, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Antonio Di ZazzoStefano Bonini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here