Cannabinoids: a new approach for pain control?

Current Opinion in Oncology
Dominique Lossignol

Abstract

To analyze available data related to the use of cannabinoids in medicine, with a special focus on pain management in cancer. The use of cannabis for medical purposes is growing but there are still numerous questions to be solved: effectiveness, safety, and specific indications. There is considerable variation between countries in the approaches taken, reflecting a variety of historical and cultural factors and despite few randomized controlled studies using natural cannabinoids, there is a trend to state that the use of cannabis should be taken seriously as a potential treatment of cancer-related pain. Cannabidiol, a nontoxic phytocannabinoid with few side-effects is promising in various indications in medicine. The endocannabinoid system is a potential therapeutic target. Cannabinoids may be considered as potential adjuvant in cancer-related pain management. Cannabidiol appears to be the drug of choice. Analgesic trial designs should evolve to get closer to real-life practice and to avoid biases.

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Citations

Aug 30, 2019·Current Opinion in Oncology·Stefan Oberndorfer, Markus Hutterer
Dec 12, 2020·Veterinary Anaesthesia and Analgesia·Cristina OrdenFrancisco J Tendillo
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ersilia NigroAurora Daniele
Jun 3, 2021·Cells·Mariantonia BraileStefania Loffredo

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