Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity

The Journal of Immunology : Official Journal of the American Association of Immunologists
Paul W WacnikMattias Svensson

Abstract

Cannabinoids affect diverse biological processes, including functions of the immune system. With respect to the immune system, anti-inflammatory and immunosuppressive effects of cannabinoids have been reported. Cannabinoids stimulate G protein-coupled cannabinoid receptors CB1 and CB2. These receptors are found primarily on neurons. However, they are also found on dendritic cells (DC), which are recognized for their critical role in initiating and maintaining immune responses. Therefore, DC are potential targets for cannabinoids. We report in this study that cannabinoids reduced the DC surface expression of MHC class II molecules as well as their capacity to stimulate T cells. In the nervous system, CB1 receptor signaling modulates K(+) and Ca(2+) channels. Interestingly, cannabinoid-treated DC also showed altered voltage-gated potassium (K(V)) channel function. We speculate that attenuation of K(V) channel function via CB1 receptor signaling in DC may represent one mechanism by which cannabinoids alter DC function.

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Citations

Apr 23, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Weimin ChenNorbert E Kaminski
May 21, 2010·The Journal of Clinical Investigation·Stefan FreigangLuc Teyton
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May 12, 2012·Mediators of Inflammation·Luciano S A CapettiniFabrizio Montecucco
Jan 21, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Valerio ChiurchiùMauro Maccarrone
Aug 23, 2010·Pharmaceuticals·Mattias SvenssonOscar Hammarfjord
Jan 7, 2021·Journal of Receptor and Signal Transduction Research·Fatma Nihan CankaraCaner Günaydın

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