Cannabinoids alter spontaneous firing, bursting, and cell synchrony of hippocampal principal cells.

Hippocampus
Anushka V GoonawardenaRobert E Hampson

Abstract

Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchronous firing of hippocampal neurons, it does not seem to affect the average firing rate. This difference is not readily explained by the chemical structure and pharmacology of the different compounds thus warranting a more detailed examination into (i) how other cannabinoids affect the spontaneous firing, bursting, and cell synchrony of hippocampal principal cells located in CA3 and CA1 subfields, and (ii) whether these effects are indeed mediated through CB1 receptors, which will be explored by the selective antagonist AM-251. Male Long-Evans rats surgically implanted with multielectrode arrays to hippocampal CA3 and CA1 were anesthetized and principal cells discharging at 0.25-6.0 Hz were isolated and "tracked" following the systemic administration of Tween-80, Δ(9)-THC (1 or 3 mg/kg) or WIN-2 (1 mg/kg) or HU-210 (100 μg/kg), and 1.5 mg/kg AM-281. All cannabinoids except for 1 mg/kg Δ(9) -THC reliably reduced averag...Continue Reading

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Citations

Dec 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Carola Sales-CarbonellDavid Robbe
May 12, 2011·Behavioural Pharmacology·Robert E HampsonSam A Deadwyler
Feb 7, 2016·Biological Psychiatry·Patrick D SkosnikMihály Hajós
May 7, 2011·British Journal of Pharmacology·Allyn C HowlettDale G Deutsch
Oct 31, 2014·Behavioural Pharmacology·Anushka V GoonawardenaGernot Riedel
Jan 15, 2015·Journal of Psychopharmacology·Jan van AmsterdamWim van den Brink
Jul 20, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Virginia M PickelGang Wang
Aug 9, 2013·Journal of Applied Research in Intellectual Disabilities : JARID·Ian Freckelton
Jul 20, 2019·Journal of Neural Transmission·Philipp GörtzChristian Lange-Asschenfeldt
Jul 3, 2021·Biology·Giulia AbateSimone Tambaro

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