Cannabinoids and cancer pain: A new hope or a false dawn?

European Journal of Internal Medicine
Matthew R D Brown, W Paul Farquhar-Smith

Abstract

The endocannabinoid system is involved in many areas of physiological function and homeostasis. Cannabinoid receptors are expressed in the peripheral and central nervous system and on immune cells, all areas ideally suited to modulation of pain processing. There are a wealth of preclinical data in a number of acute, chronic, neuropathic and cancer pain models that have demonstrated a potent analgesic potential for cannabinoids, especially in patients with cancer. However, although there are some positive results in pain of cancer patients, the clinical evidence for cannabinoids as analgesics has not been convincing and their use can only be weakly recommended. The efficacy of cannabinoids seems to have been 'lost in translation' which may in part be related to using extracts of herbal cannabis rather than targeted selective full agonists at the cannabinoid CB1 and CB2 receptors.

Citations

Jun 21, 2018·British Journal of Clinical Pharmacology·Meera Agar
Feb 23, 2019·Current Opinion in Oncology·Dominique Lossignol
Jan 27, 2019·Pain Management·Sara P KhanDaniel J Berlau
Jul 30, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Wen S ShengJames R Lokensgard
Aug 26, 2020·International Journal of Molecular Sciences·Ava BachariNitin Mantri
Dec 29, 2019·Scientific Reports·David André BarrièrePhilippe Sarret
Oct 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia SunDa-Wei Ye

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