Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect.

Neuroscience Letters
Ahmet DogrulM Erdal Güzeldemir

Abstract

Diabetic neuropathic pain is one of the most commonly encountered neuropathic pain syndromes. However, the treatment of diabetic neuropathic pain is challenging because of partial effectiveness of currently available pain relievers. It is well known that diabetic animals are less sensitive to the analgesic effect of morphine, and opioids are found to be ineffective in the treatment of diabetic neuropathic pain. Cannabinoids are promising drugs and they share a similar pharmacological properties with opioids. It has been reported that cannabinoid analgesia remained intact and to be effective in some models of nerve injury. Thus, we investigated antinociceptive efficacy and the effects of cannabinoids on behavioral sign of diabetic neuropathic pain in diabetic mice by using WIN 55, 212-2, a cannabinoid receptor agonist. Diabetes was induced by streptozotocin (STZ) (200mg/kg) and animals were tested between 45 and 60 days after onset of diabetes. Antinociception was assessed using the radiant tail-flick test. Mechanical and thermal sensitivities were measured by Von Frey filaments and hot-plate test, respectively. Tactile allodynia, but not thermal hyperalgesia developed in diabetic mice. Systemic WIN 55, 212-2 (1, 5 and 10mg/kg) ...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HerkenhamK C Rice
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Feb 12, 2000·Diabetes Research and Clinical Practice·B S GalerM P Jensen
Mar 4, 2000·Neuroscience Letters·J MaoD J Mayer
Jun 26, 2001·The European Journal of Neuroscience·L J HudsonJ Winter
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hua-Sheng XiaoXu Zhang
Feb 11, 2003·Diabetes/metabolism Research and Reviews·Dilip Kapur
Sep 23, 2003·Pain·Ozgur YesilyurtOguzhan Yildiz
Nov 13, 2003·Current Diabetes Reports·Singhan T M Krishnan, Gerry Rayman

❮ Previous
Next ❯

Citations

Sep 10, 2008·Current Pain and Headache Reports·Michael L Oshinsky
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elizabeth J Rahn, Andrea G Hohmann
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Devi Rani SagarVictoria Chapman
Jul 8, 2008·CNS Drugs·M Isabel Martín Fontelles, Carlos Goicoechea García
Mar 2, 2010·Future Medicinal Chemistry·Prakash NagarkattiMitzi Nagarkatti
Jun 16, 2009·Canadian Journal of Physiology and Pharmacology·Parisa HasaneinAli Roohbakhsh
Mar 10, 2010·Brain Research·Ahmad Mohammadi-FaraniMahmoud Ghazi-Khansari
Feb 13, 2008·Journal of Cellular and Molecular Medicine·L GianniniE Masini
May 19, 2012·Arthritis and Rheumatism·Mary-Ann FitzcharlesIvan Padjen
Jul 19, 2005·Journal of Neuroimmunology·J Ludovic Croxford, Takashi Yamamura
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fernando EzquerPaulette Conget
Apr 7, 2015·The Journal of Pain : Official Journal of the American Pain Society·Mark S WallaceJoseph H Atkinson
May 23, 2012·Pharmacology, Biochemistry, and Behavior·Gema VeraRaquel Abalo
Feb 26, 2015·Pharmacological Reports : PR·Magdalena Bujalska-ZadrożnyKarolina Pawlik
Feb 2, 2006·The Annals of Pharmacotherapy·Tammy L Burns, Joseph R Ineck
Sep 1, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giulia DonvitoAron H Lichtman
Mar 14, 2019·Journal of Medicinal Food·Dalia Samanta Aguilar-ÁvilaJuan Manuel Viveros-Paredes
May 15, 2009·Phytotherapy Research : PTR·Francesca ComelliBarbara Costa
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jasmine Siew Min ChiaEnoch Kumar Perimal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.