Cannabinoids in Chronic Non-Cancer Pain: A Systematic Review and Meta-Analysis

Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
Herman JohalMohit Bhandari

Abstract

For patients with chronic, non-cancer pain, traditional pain-relieving medications include opioids, which have shown benefits but are associated with increased risks of addiction and adverse effects. Medical cannabis has emerged as a treatment alternative for managing these patients and there has been a rise in the number of randomized clinical trials in recent years; therefore, a systematic review of the evidence was warranted. To analyze the evidence surrounding the benefits and harms of medical cannabinoids in the treatment of chronic, non-cancer-related pain. Systematic review with meta-analysis. Medline, Embase, CINAHL, SCOPUS, Google Scholar, and Cochrane Databases. English language randomized clinical trials of cannabinoids for the treatment of chronic, non-cancer-related pain. Study quality was assessed using the Cochrane risk of bias tool. All stages were conducted independently by a team of 6 reviewers. Data were pooled through meta-analysis with different durations of treatment (2 weeks, 2 months, 6 months) and stratified by route of administration (smoked, oromucosal, oral), conditions, and type of cannabinoids. Patient-reported pain and adverse events (AEs). Thirty-six trials (4006 participants) were included, exam...Continue Reading

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Citations

Apr 26, 2020·International Journal of Molecular Sciences·Antonelly Cassio Alves de CarvalhoSandra M Barbalho
Jul 14, 2020·Therapeutic Advances in Musculoskeletal Disease·Herman JohalMohit Bhandari
Aug 29, 2020·BioMed Research International·Marta VázquezPaula Schaiquevich
Sep 29, 2020·NeuroRehabilitation·Allison KesslerRandy Calisoff
Dec 6, 2020·Obstetrics and Gynecology·Roxana GeoffrionPaul J Yong
Oct 19, 2020·The Journal of Pain : Official Journal of the American Pain Society·Ming Tatt LeeLih-Chu Chiou
Feb 23, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Yaping ChangMohit Bhandari
Jul 12, 2020·Current Opinion in Psychology·Irene BraithwaiteGiles Newton-Howes
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Jul 20, 2021·Brazilian Journal of Anesthesiology·Camila Pantoja-RuizDiego Rosselli
Sep 2, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Markus KöstenbergerRudolf Likar
Oct 9, 2021·Journal of Pain & Palliative Care Pharmacotherapy·Juan Camilo Sánchez-FlórezSebastian Amaya

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Software Mentioned

Cochrane Risk of Bias
OrthoEvidence
OE
Review Manager
STATA
GRADE

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