Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors

Pain
Jennelle Durnett RichardsonKenneth M Hargreaves

Abstract

Central antinociceptive effects of cannabinoids have been well documented. However, relatively little is known about the peripheral effects of the cannabinoids on inflammation. In the present study, we evaluated the effects of peripherally administered cannabinoids on three indices of inflammation: carrageenan-induced thermal hyperalgesia, carrageenan-induced edema, and capsaicin-induced plasma extravasation. In addition, we determined the effect of cannabinoids on capsaicin-evoked neuropeptide release from isolated rat hindpaw skin. Our results indicate that cannabinoids produce antihyperalgesia via interaction with a peripheral CB1 receptor. Peripheral, but not systemic, administration of 0.01 ng anandamide inhibited the induction of hyperalgesia. Peripheral administration of anandamide also attenuated hyperalgesia after its development via interaction with the CB1 cannabinoid receptor subtype as indicated by its reversal with the CB1 receptor antagonist SR 141716A. Additionally, peripheral, but not systemic, administration of 0.01 ng anandamide inhibited edema. Peripherally administered cannabinoids also interacted with CB1 receptors to inhibit capsaicin-evoked plasma extravasation into the hindpaw. One potential mechanism f...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Mackie, B Hille
Jul 7, 1992·European Journal of Pharmacology·A NagahisaH J Hess
May 15, 1986·Neuroscience Letters·P W Reeh
Oct 1, 1973·European Journal of Pharmacology·D S KoserskyL S Harris
Aug 1, 1981·Journal of Clinical Pharmacology·M R JohnsonA Weissman
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·E M Johnson
Aug 25, 1995·European Journal of Pharmacology·M D AcetoB R Martin
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·L FacciA Leon
Feb 24, 1995·The Journal of Biological Chemistry·D ShireP Ferrara
Jun 10, 1994·Journal of Medicinal Chemistry·V AbadjiA Makriyannis
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderW A Devane
Oct 1, 1993·Journal of Medicinal Chemistry·L HanusR Mechoulam
May 26, 1998·European Journal of Pharmacology·J D RichardsonK M Hargreaves
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A H LichtmanB R Martin
Oct 7, 2004·European Journal of Pharmacology·Lorand BarthóOrs-Peter Horváth

❮ Previous
Next ❯

Citations

Nov 19, 2004·Der Schmerz·R RukwiedC Konrad
May 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wei WangLieju Liu
Jun 7, 2005·Life Sciences·Luciano De Petrocellis, Vincenzo Di Marzo
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Christopher J FowlerStig O P Jacobsson
Dec 31, 2002·Chemistry and Physics of Lipids·George KunosJudith Harvey-White
Dec 31, 2002·Chemistry and Physics of Lipids·T Philip MalanFrank Porreca
May 24, 2000·European Journal of Pharmacology·P Beaulieu1A S Rice
Jun 28, 2001·European Journal of Pharmacology·A CalignanoD Piomelli
Nov 8, 2001·European Journal of Pharmacology·V MorissetL Urban
Dec 6, 2001·European Journal of Pharmacology·S R SmithC Terminelli
Jul 16, 2003·European Journal of Pharmacology·Vera Ralevic
May 26, 1998·European Journal of Pharmacology·J D RichardsonK M Hargreaves
Aug 26, 1999·Life Sciences·J M WalkerK Tsou
Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Aug 17, 2002·Pharmacology & Therapeutics·J Michael Walker, Susan M Huang
Jul 27, 2002·Orvosi hetilap·Zoltán Járai, György Kúnos
Jun 6, 2000·Trends in Pharmacological Sciences·D PiomelliF Rodríguez de Fonseca
Jun 6, 2000·Trends in Pharmacological Sciences·J Szolcsányi
Jul 3, 1999·Trends in Pharmacological Sciences·J ManzanaresJ A Fuentes
Feb 9, 2000·Trends in Pharmacological Sciences·P M ZygmuntE D Högestätt
Feb 9, 2000·Trends in Pharmacological Sciences·J Szolcsányi
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Feb 13, 2001·Progress in Neurobiology·R G Pertwee
May 30, 2002·Progress in Neurobiology·Mark J Millan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here