Cannabis, a Significant Risk Factor for Violent Behavior in the Early Phase Psychosis. Two Patterns of Interaction of Factors Increase the Risk of Violent Behavior: Cannabis Use Disorder and Impulsivity; Cannabis Use Disorder, Lack of Insight and Treatment Adherence

Frontiers in Psychiatry
Valerie MoulinPhilippe Conus

Abstract

Background: Previous literature suggests that prevalence of cannabis use in the early phase of psychosis is high, and that early psychosis patients are at high-risk for violent behavior. However, the link between cannabis use and violent behavior in early psychosis patients is unclear. We carried out a study on a sample of early psychosis patients, in order to explore the impact of cannabis use on the risk of violent behavior (VB), while taking into account (1) potential confounding factors and, (2) interactions with other dynamic risk factors of VB. Method: In a sample of 265 early psychosis patients, treated at the Treatment and Early Intervention in Psychosis Program (TIPP) in Lausanne, we used logistic regression models to explore the link between various dynamic risk factors of VB [positive symptoms, substance use disorder (drugs including cannabis, alcohol and others drugs), insight, impulsivity, affective instability, and treatment adherence], and VB occurring during treatment. In order to understand hierarchical effects attributable to the combinations of risk factors on VB we conducted a Classification and Regression Tree (CART). Results: Our results show that cannabis use disorder is a risk factor for VB. The associat...Continue Reading

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Citations

Jan 31, 2020·Frontiers in Psychiatry·Margo D M FaayUNKNOWN Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Mar 4, 2020·International Journal of Environmental Research and Public Health·Norman S MillerThersilla Oberbarnscheidt
Jul 17, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Valerie MoulinPhilippe Conus
Aug 30, 2019·Psychological Medicine·Jelle LamsmaUNKNOWN GROUP and NEDEN investigators
Mar 26, 2021·The Journal of Nervous and Mental Disease·Stephanie A RolinPaul S Appelbaum

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