Cannabis and cannabinoid receptors: from pathophysiology to therapeutic options

Revue neurologique
P DerkinderenJ-A Girault

Abstract

Although cannabis has been used as a medicine for several centuries, the therapeutic properties of cannabis preparations (essentially haschich and marijuana) make them far most popular as a recreational drugs. Scientific studies on the effects of cannabis were advanced considerably by the identification in 1964 of cannabinoid D9-tetrahydrocannadinol (THC), recognized as the major active constituent of cannabis. Cloning of the centrally located CB1 receptor in 1990 and the identification of the first endogenous ligand of the CB1 receptor, anandamide, in 1992 further advanced our knowledge. Progress has incited further research on the biochemistry and pharmacology of the cannabinoids in numerous diseases of the central nervous system. In the laboratory animal, cannabinoids have demonstrated potential in motion disorders, demyelinizing disease, epilepsy, and as anti-tumor and neuroprotector agents. Several clinical studies are currently in progress, but therapeutic use of cannabinoids in humans couls be hindered by undesirable effects, particularly psychotropic effects. CB1 receptor antagonists also have interesting therapeutic potential.

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Mackie, B Hille
Oct 1, 1991·The Biochemical Journal·C M GérardM Parmentier
Feb 1, 1989·Journal of Neurology·H M MeinckB Conrad
Jun 5, 1970·Science·R Mechoulam
Aug 1, 1981·Journal of Clinical Pharmacology·D J Petro, C Ellenberger
Jun 1, 1983·Annals of Neurology·D B Clifford
Oct 4, 1995·Biochemical and Biophysical Research Communications·T SugiuraK Waku
Mar 1, 1994·Clinical Pharmacology and Therapeutics·H S GreenbergE F Domino
Mar 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P C ChanJ R Bucher
Jul 1, 1997·Journal of Neurophysiology·W TwitchellK Mackie
Jan 1, 1997·European Neurology·P ConsroeR Pertwee
Aug 26, 1998·Immunology Today·T W KleinH Friedman
Oct 15, 1998·FEBS Letters·C SánchezM Guzmán
Jan 8, 1999·Acta Psychiatrica Scandinavica·K R Müller-VahlH M Emrich
Mar 18, 1999·Biochemical and Biophysical Research Communications·T BisognoV Di Marzo
Apr 16, 1999·Nature Neuroscience·A GiuffridaD Piomelli
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ZimmerT I Bonner
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·K R Müller-VahlH M Emrich
Jun 6, 2000·Trends in Pharmacological Sciences·D PiomelliF Rodríguez de Fonseca
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V Di MarzoJ M Brotchie
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E Straus
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D BakerV Di Marzo
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·P Robson
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·L HanusR Mechoulam

❮ Previous
Next ❯

Citations

Mar 17, 2006·Journal of Ethnopharmacology·Mohamed Ben Amar
Aug 16, 2017·Pediatrics·Isabelle ClaudetUNKNOWN Marie-Jeanne Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives des maladies du coeur et des vaisseaux
Y JuilletE Housset
© 2022 Meta ULC. All rights reserved