Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies

Pain
Emily StockingsLouisa Degenhardt

Abstract

This review examines evidence for the effectiveness of cannabinoids in chronic noncancer pain (CNCP) and addresses gaps in the literature by: considering differences in outcomes based on cannabinoid type and specific CNCP condition; including all study designs; and following IMMPACT guidelines. MEDLINE, Embase, PsycINFO, CENTRAL, and clinicaltrials.gov were searched in July 2017. Analyses were conducted using Revman 5.3 and Stata 15.0. A total of 91 publications containing 104 studies were eligible (n = 9958 participants), including 47 randomised controlled trials (RCTs) and 57 observational studies. Forty-eight studies examined neuropathic pain, 7 studies examined fibromyalgia, 1 rheumatoid arthritis, and 48 other CNCP (13 multiple sclerosis-related pain, 6 visceral pain, and 29 samples with mixed or undefined CNCP). Across RCTs, pooled event rates (PERs) for 30% reduction in pain were 29.0% (cannabinoids) vs 25.9% (placebo); significant effect for cannabinoids was found; number needed to treat to benefit was 24 (95% confidence interval [CI] 15-61); for 50% reduction in pain, PERs were 18.2% vs 14.4%; no significant difference was observed. Pooled change in pain intensity (standardised mean difference: -0.14, 95% CI -0.20 to -...Continue Reading

Associated Clinical Trials

References

Jan 1, 1990·European Archives of Psychiatry and Clinical Neuroscience·M MaurerA Hofmann
Feb 28, 2002·BMC Medical Research Methodology·Christopher J Cates
Mar 27, 2002·International Journal of Epidemiology·Diana R ElbourneAndy Vail
Sep 5, 2002·Statistics in Medicine·François CurtinDouglas G Altman
Sep 5, 2002·Statistics in Medicine·François CurtinDouglas G Altman
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Matthias KarstUdo Schneider
Oct 4, 2003·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jacques Simon LeeGeorge A Wells
Dec 18, 2003·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Zvia RudichStephen C Brown
Jun 14, 2005·Best Practice & Research. Clinical Rheumatology·Raymond W J G Ostelo, Henrica C W de Vet
Nov 3, 2007·The Journal of Pain : Official Journal of the American Pain Society·Ryan Quinlan SkrabekDaryl Perry
Dec 7, 2007·The Journal of Pain : Official Journal of the American Pain Society·Robert H DworkinStojan Zavisic
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·Sanjeet NarangRobert N Jamison
Apr 12, 2008·The Journal of Pain : Official Journal of the American Pain Society·Barth WilseyScott Fishman
Aug 9, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronald J EllisJ Hampton Atkinson
Sep 10, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Finlay A McAlister
Oct 20, 2009·Lancet·Wayne Hall, Louisa Degenhardt
Dec 17, 2009·Anesthesia and Analgesia·Mark A WareYoram Shir
Sep 2, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Mark A WareJean-Paul Collet
Sep 22, 2010·American Journal of Physical Medicine & Rehabilitation·Diana H RintalaBrian M Bruel
Nov 23, 2010·Pain Practice : the Official Journal of World Institute of Pain·Jennifer A Bestard, Cory C Toth
Mar 3, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A NovotnaUNKNOWN Sativex Spasticity Study Group
May 16, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jody Corey-BloomBen Gouaux
Jul 14, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·John Peter ZajicekUNKNOWN MUSEC Research Group
Dec 15, 2012·The Journal of Pain : Official Journal of the American Pain Society·Barth WilseyHaylee Donaghe
Apr 26, 2013·BMJ : British Medical Journal·Agnes DechartresPhilippe Ravaud

❮ Previous
Next ❯

Citations

Aug 24, 2018·British Journal of Clinical Pharmacology·Jennifer H Martin, Noel Cranswick
Mar 29, 2019·BMJ : British Medical Journal·Mark E Lloyd, Karin Cannons
Apr 18, 2019·The American Journal of Bioethics : AJOB·David Casarett, Donald I Abrams
Jul 26, 2019·Current Pain and Headache Reports·Ivan UritsOmar Viswanath
Mar 23, 2019·Pharmacological Reviews·S Stevens Negus
Aug 10, 2019·JAMA : the Journal of the American Medical Association·Kevin P Hill
Oct 17, 2019·Anais Da Academia Brasileira De Ciências·Chaowalit MontonThanapat Songsak
Jul 7, 2019·Clinical Rheumatology·Glen S HazlewoodMary-Ann Fitzcharles
Sep 22, 2019·Der Schmerz·Frank PetzkeUNKNOWN Ad-hoc-Kommission der Deutschen Schmerzgesellschaft „Cannabis in der Medizin“
Dec 19, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marcello Mario MasciaGiovanni Defazio
Oct 2, 2019·Journal of Neurochemistry·Nicholas AtwalChristopher W Vaughan
Sep 25, 2019·Drug and Therapeutics Bulletin
Sep 20, 2019·Journal of Anesthesia·Mari Kannan MaharajanKai Xian Yap
Jul 30, 2019·Current Opinion in Anaesthesiology·Haggai Sharon, Silviu Brill
Feb 29, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Zach Walsh
Apr 23, 2020·International Journal of Molecular Sciences·Adam StasiulewiczAnd Joanna I Sulkowska
Apr 26, 2020·Current Opinion in Supportive and Palliative Care·Howard MengHance Clarke
Mar 11, 2020·Trauma Surgery & Acute Care Open·Elisabeth Schneider-SmithDavid Bar-Or
May 7, 2020·Clinical Gerontologist·Namkee G ChoiBryan Y Choi
Jun 20, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ramin SafakishSun Young Rosalia Yoon
May 31, 2020·Regional Anesthesia and Pain Medicine·Faraj W AbdallahRichard Brull
Aug 10, 2020·Clinical Pharmacology and Therapeutics·Luca EibachChristoph Stein
Jan 13, 2019·European Archives of Psychiatry and Clinical Neuroscience·Gabrielle CampbellSuzanne Nielsen
Oct 18, 2019·Brain Injury : [BI]·David W LawrenceMark Bayley
Jan 17, 2020·Geriatrics·William BeedhamDavid Shipway
May 7, 2020·Current Opinion in Anaesthesiology·Rachael S Rzasa Lynn, Jeffrey L Galinkin
Jul 25, 2020·Current Pain and Headache Reports·Mariam Salisu OrhurhuVwaire Orhurhu
Apr 6, 2019·BMJ : British Medical Journal·Tom P FreemanMichael A P Bloomfield
Mar 17, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Stanley Sau Ching WongChi Wai Cheung
Dec 4, 2019·Addiction Science & Clinical Practice·Devan KansagaraJeanette M Tetrault
Mar 18, 2020·The Journal of Pharmacology and Experimental Therapeutics·Stevie C BritchRebecca M Craft
Mar 5, 2020·British Journal of Clinical Pharmacology·Jennifer H MartinJose Crippa
Jun 30, 2019·PloS One·Joanna S ZeigerRobert S Zeiger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
Martin MückeW Häuser
The Cochrane Database of Systematic Reviews
Patrick WelschW Häuser
The Cochrane Database of Systematic Reviews
Brian WalittW Häuser
The Cochrane Database of Systematic Reviews
Sheena DerryR Andrew Moore
© 2022 Meta ULC. All rights reserved