Cannabis in cancer care

Clinical Pharmacology and Therapeutics
D I Abrams, M Guzman

Abstract

Cannabis has been used in medicine for thousands of years prior to achieving its current illicit substance status. Cannabinoids, the active components of Cannabis sativa, mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervous system and CB2 found predominantly in cells involved with immune function. Delta-9-tetrahydrocannabinol, the main bioactive cannabinoid in the plant, has been available as a prescription medication approved for treatment of cancer chemotherapy-induced nausea and vomiting and anorexia associated with the AIDS wasting syndrome. Cannabinoids may be of benefit in the treatment of cancer-related pain, possibly synergistic with opioid analgesics. Cannabinoids have been shown to be of benefit in the treatment of HIV-related peripheral neuropathy, suggesting that they may be worthy of study in patients with other neuropathic symptoms. Cannabinoids have a favorable drug safety profile, but their medical use is predominantly limited by their psychoactive effects and their limited bioavailability.

References

Jul 1, 1975·Clinical Pharmacology and Therapeutics·R NoyesA C Canter
Feb 11, 1975·Journal of Clinical Pharmacology·R NoyesA Canter
Oct 16, 1975·The New England Journal of Medicine·S E SallanE Frei
Sep 1, 1975·Journal of the National Cancer Institute·A E MunsonR A Carchman
Nov 1, 1974·Comprehensive Psychiatry·R Noyes, D A Baram
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·L FacciA Leon
Feb 1, 1995·Journal of Pain and Symptom Management·J E BealK V Shepard
Nov 5, 1997·Cancer Causes & Control : CCC·S SidneyI S Tekawa
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·L De PetrocellisV Di Marzo
Mar 6, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Declan WalshFade Aziz Mahmoud
Oct 23, 2003·Nature Reviews. Cancer·Manuel Guzmán
Jan 7, 2004·Life Sciences·Diana L Cichewicz
Feb 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mohab M IbrahimT Philip Malan
Mar 9, 2005·Cancer Research·Sami SarfarazHasan Mukhtar
Jul 27, 2005·Biochemical Society Transactions·H A PatsosC Paraskeva
Feb 28, 2006·British Journal of Pharmacology·Maurizio BifulcoPatrizia Gazzerro
Mar 17, 2006·Journal of Ethnopharmacology·Mohamed Ben Amar
Mar 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R MechoulamE Fride
Jul 13, 2006·Archives of Internal Medicine·Reena MehraDavid A Fiellin
Oct 13, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mia HashibeSander Greenland
Apr 5, 2007·The Oncologist·Frederike K EngelsRon H J Mathijssen
Apr 12, 2008·The Journal of Pain : Official Journal of the American Pain Society·Barth WilseyScott Fishman
Aug 9, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronald J EllisJ Hampton Atkinson
Feb 11, 2009·Cancer·Janet R DalingStephen M Schwartz
Feb 20, 2009·British Journal of Pharmacology·Roger G Pertwee
Sep 2, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Mark A WareJean-Paul Collet
Oct 7, 2010·Cancer·Britton TrabertKatherine A McGlynn
Jan 12, 2011·Molecular Cancer Therapeutics·Sofía TorresGuillermo Velasco
Feb 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T D BrisboisW V Wismer
Jul 14, 2011·British Journal of Pharmacology·Ethan B Russo
Aug 27, 2011·American Journal of Epidemiology·Yann Le Strat, Bernard Le Foll
Oct 25, 2011·Critical Reviews in Oncology/hematology·Daniel W BowlesAntonio Jimeno
Nov 4, 2011·Clinical Pharmacology and Therapeutics·D I AbramsN L Benowitz
May 5, 2012·Nature Reviews. Cancer·Guillermo VelascoManuel Guzmán

❮ Previous
Next ❯

Citations

Mar 25, 2015·Clinical Pharmacology and Therapeutics·B Le Foll, R F Tyndale
Jun 17, 2016·Journal of Medicinal Chemistry·Paula MoralesNadine Jagerovic
Aug 25, 2016·Drug Discovery Today·Oier Aizpurua-OlaizolaAresatz Usobiaga
Dec 1, 2017·The Cancer Journal·Michael W RabowSarah H Adkins
Jul 24, 2018·Clinical Journal of Oncology Nursing·Sarah Merkle, Susan S Tavernier
Aug 18, 2018·Journal of Psychoactive Drugs·Rachel L Goldberg, Janine K Cataldo
Aug 2, 2016·Journal of Primary Health Care·Nataly Martini
Sep 25, 2019·Medicina·Ayappa V SubramaniamChern Ein Oon
Feb 4, 2016·Current Opinion in Ophthalmology·Gary D Novack
Jun 5, 2019·Current Treatment Options in Oncology·Donald I Abrams
Feb 27, 2020·Journal of Palliative Medicine·Ian M PawasaratTae Won B Kim
Jul 18, 2020·Journal of Adolescent and Young Adult Oncology·Joseph E RowerJonathan E Constance
Nov 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chih-Wei ChangYu-Tse Wu
Aug 1, 2018·Laryngoscope Investigative Otolaryngology·Lucas M BryantJoseph M Curry
May 16, 2020·The Journal of International Medical Research·Razia Abdool Gafaar KhammissaLiviu Feller
May 25, 2016·Current Oncology Reports·Shauna M BirdsallLucas A Tims
Aug 22, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Todd W Mattox
Jun 6, 2018·Frontiers in Systems Neuroscience·Dale E Bjorling, Zun-Yi Wang
Dec 14, 2018·Frontiers in Pharmacology·Sonja VučkovićMilica Prostran
Aug 16, 2019·Therapeutic Advances in Medical Oncology·Amber S KlecknerLuke J Peppone
May 1, 2019·Natural Product Research·Daniela De VitaRoberto Di Santo
Apr 15, 2020·Analytical and Bioanalytical Chemistry·Cinzia CittiGiuseppe Cannazza
May 10, 2018·Frontiers in Oncology·Sayeda Yasmin-KarimWilfred Ngwa
Oct 28, 2019·Journal of Primary Care & Community Health·Deepika SlawekRobert Cook
May 11, 2018·Proteomics·Xiang LiHubert Hondermarck
Oct 8, 2020·Journal of the American Geriatrics Society·Kevin H YangAlison A Moore
Oct 20, 2020·The Annals of Pharmacotherapy·Lindsey Sawtelle, Lisa M Holle
Jan 14, 2021·Current Treatment Options in Oncology·Mahmoud Abu-AmnaGil Bar-Sela
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Samridhi LalSubash C Gupta
Nov 17, 2020·Complementary Therapies in Medicine·Yuval ZolotovOfir Morag
Feb 2, 2021·Trends in Analytical Chemistry : TRAC·Sharda KotruMatiar M R Howlader

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Declan WalshFade Aziz Mahmoud
Recenti progressi in medicina
Ali Muftah ShaladiBruno Piva
© 2021 Meta ULC. All rights reserved