Cannabis in Parkinson's Disease: The Patients' View.

Journal of Parkinson's Disease
Ferhat YenilmezCarsten Buhmann

Abstract

Little is known about the patients' view on treatment with medical cannabis (MC) for Parkinson's disease (PD). To assess the PD community's perception of MC and patients' experience with MC. Applying a questionnaire-based survey, we evaluated general knowledge and interest in MC as well as the frequency, modalities, efficacy, and tolerability of application. Questionnaires were distributed nationwide via the membership journal of the German Parkinson Association and locally in our clinic to control for report bias. Overall, 1.348 questionnaires (1.123 nationwide, 225 local) were analysed. 51% of participants were aware of the legality of MC application, 28% of various routes of administration (ROA) and 9% of the difference between delta9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). PD-related cannabis use was reported by 8.4% of patients and associated with younger age, living in large cities and better knowledge about the legal and clinical aspects of MC. Reduction of pain and muscle cramps was reported by more than 40% of cannabis users. Stiffness/akinesia, freezing, tremor, depression, anxiety and restless legs syndrome subjectively improved for more than 20% and overall tolerability was good. Improvement of symptoms...Continue Reading

References

May 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·J P FrankelG M Stern
Jun 11, 2004·Clinical Neuropharmacology·V MesnageY Agid
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Katerina VenderováPeter Visnovský
May 3, 2005·Nature Reviews. Immunology·Thomas W Klein
Sep 20, 2008·Journal of Psychopharmacology·A W ZuardiV Tumas
Mar 17, 2010·Expert Opinion on Therapeutic Targets·Javier Fernández-RuizEva de Lago
Jun 19, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Derick T WadePaul Duncombe
Mar 2, 2013·Nature Reviews. Drug Discovery·Paul EnckWinfried Rief
Sep 23, 2014·Journal of Psychopharmacology·Marcos Hortes N ChagasJosé Alexandre S Crippa
Jun 24, 2015·JAMA : the Journal of the American Medical Association·Penny F WhitingJos Kleijnen
Jul 29, 2015·British Journal of Pharmacology·R B LaprairieE M Denovan-Wright
Oct 24, 2017·Clinical Neuropharmacology·Yacov BalashTanya Gurevich
Nov 8, 2017·Frontiers in Pharmacology·Eva Martínez-PinillaRafael Franco
Jan 13, 2018·Fortschritte der Neurologie-Psychiatrie·Tina MainkaCarsten Buhmann
May 24, 2019·Experimental and Clinical Psychopharmacology·Julio A YanesJennifer L Robinson
May 28, 2019·Journal of Neural Transmission·Carsten BuhmannFlorin Gandor

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Citations

Mar 31, 2021·Current Opinion in Supportive and Palliative Care·Katarina RukavinaKirsty Bannister
May 20, 2021·Current Opinion in Supportive and Palliative Care·Katarina RukavinaKirsty Bannister
Jul 6, 2021·Drugs & Aging·Veit MyliusSantiago Perez Lloret

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