Cannabis-related episodic memory deficits and hippocampal morphological differences in healthy individuals and schizophrenia subjects

Hippocampus
Matthew J SmithJ G Csernansky

Abstract

Cannabis use has been associated with episodic memory (EM) impairments and abnormal hippocampus morphology among both healthy individuals and schizophrenia subjects. Considering the hippocampus' role in EM, research is needed to evaluate the relationship between cannabis-related hippocampal morphology and EM among healthy and clinical groups. We examined differences in hippocampus morphology between control and schizophrenia subjects with and without a past (not current) cannabis use disorder (CUD). Subjects group-matched on demographics included 44 healthy controls (CON), 10 subjects with a CUD history (CON-CUD), 28 schizophrenia subjects with no history of substance use disorders (SCZ), and 15 schizophrenia subjects with a CUD history (SCZ-CUD). Large-deformation, high-dimensional brain mapping with MRI produced surface-based representations of the hippocampus that were compared across all four groups and correlated with EM and CUD history. Surface maps of the hippocampus were generated to visualize morphological differences. CON-CUD and SCZ-CUD were characterized by distinct cannabis-related hippocampal shape differences and parametric deficits in EM performance. Shape differences observed in CON-CUD were associated with poo...Continue Reading

References

Aug 17, 2001·NeuroImage·L WangJ G Csernansky
Nov 27, 2002·The American Journal of Psychiatry·John G CsernanskyMichael I Miller
Jan 6, 2004·The Clinical Neuropsychologist·Mike R SchoenbergRussell L Adams
Jan 7, 2004·Biological Psychiatry·Arthur L BrodyEdythe D London
Aug 26, 2004·Journal of the International Neuropsychological Society : JINS·Otto PedrazaRobin Gilmore
Apr 5, 2005·The American Journal on Addictions·Golfo K TzilosDeborah A Yurgelun-Todd
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cécile HenquetJim van Os
Oct 5, 2006·Psychopharmacology·Mohini Ranganathan, Deepak Cyril D'Souza
Apr 5, 2007·Hippocampus·Cynthia Mills SchumannDavid G Amaral
Jun 4, 2008·Archives of General Psychiatry·Murat YücelDan I Lubman
Sep 9, 2008·Schizophrenia Research·Matthew J SmithJohn G Csernansky
Jul 30, 2009·Neuropsychology Review·Victoria M Leavitt, Terry E Goldberg
Dec 17, 2009·Journal of School Psychology·Amanda N Baraldi, Craig K Enders
Jun 23, 2010·Bipolar Disorders·Daniel MamahDeanna M Barch
Feb 8, 2011·Journal of Psychiatric Research·Manzar AshtariSanjiv Kumra
Feb 12, 2011·Current Topics in Behavioral Neurosciences·Stephan Heckers, Christine Konradi
Jan 31, 2012·Psychiatry Research·Austin A Woolard, Stephan Heckers
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Madeline H MeierTerrie E Moffitt
Dec 4, 2012·Schizophrenia Research·Nadia SolowijMurat Yücel
Apr 30, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Sarah L M JohnsonNitin Gogtay
Aug 22, 2013·Journal of the International Neuropsychological Society : JINS·Natania A CraneRaul Gonzalez
Oct 15, 2013·Psychiatry and Clinical Neurosciences·Matteo RocchettiPaolo Fusar-Poli

❮ Previous
Next ❯

Citations

Jul 19, 2015·Behavioural Brain Research·Francesca M FilbeyAriel Ketcherside
May 12, 2015·Neuroscience and Biobehavioral Reviews·Alejandro Higuera-MatasEmilio Ambrosio
Jan 13, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·New Fei HoJuan Zhou
Apr 4, 2021·Behavioral Sciences·Alessandro FrolliLuisa Franzese
Jun 5, 2017·Journal of Psychiatric Research·Daniela Rodrigues-AmorimRoberto C Agís-Balboa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.