Cannabis smoke can be a major risk factor for early-age laryngeal cancer--a molecular signaling-based approach

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Sayantan BhattacharyyaNabendu Murmu

Abstract

Epidermal growth factor receptor (EGFR) and its downstream elements are overexpressed in most cases of the head and neck squamous cell carcinoma. This study investigated the expression pattern of key proteins linked to the EGFR pathway in laryngeal carcinoma patients with a history of cannabis smoking. We selected 83 male glottic cancer patients, aged between 45 to 75 years with three distinct populations-nonsmoker, cigarette smoker, and cannabis smoker. Immunohistochemical staining was performed for EGFR, protein kinase B (PKB or Akt), nuclear factor kappa B p50 (NF-КB), and cyclooxygenase-2 (COX-2) followed by boolean scoring for statistical analysis. Experimental data showed upregulation of the selected EGFR cascade in tumor cells, stromal expression of EGFR, and nuclear localization of COX-2 in metaplastic gland cells of laryngeal cancer tissue sample. Statistical analyses indicated that overexpression of the EGFR cascade is significantly correlated to cannabis smoking. Cannabis smokers had higher expression (p < 0.01) of these onco-proteins with respect to both nonsmokers as well as cigarette smokers. Risk factor analysis showed high risk of these proteins expression in age <60 years (odds ratio (OR) > 1.5) as the lower ag...Continue Reading

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Citations

Jul 1, 2016·Head and Neck Pathology·Stephen M SmithO Hans Iwenofu
Jul 13, 2019·The American Journal of Drug and Alcohol Abuse·Donald P Tashkin, Michael D Roth
Jan 1, 2017·Cellular Oncology (Dordrecht)·Sayantan BhattacharyyaNabendu Murmu
Jan 7, 2021·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Catriona M DouglasJenny Montgomery
Nov 30, 2020·The Annals of Thoracic Surgery·Amber FamigliettiPuja Gaur Khaitan
Sep 29, 2021·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Jobanjit S PhulkaAmanda Hu

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