Cannabis smoking impairs driving performance on the simulator and real driving: a randomized, double-blind, placebo-controlled, crossover trial

Fundamental & Clinical Pharmacology
Joëlle MicallefDaniel Mestre

Abstract

Driving experiments in real conditions are considered as a 'gold standard' to evaluate the effects of drugs on driving performance. Several constraints are difficult to manage in these conditions, so driving simulation appears as the best alternative. A preliminary comparison is crucial before being able to use driving simulation as a valid evaluation method. The aim of this study was to design a driving simulation method for assessing drug effects on driving. We used cannabis (THC) as a positive control and assessed whether THC affects driving performance in simulation conditions and whether these effects are consistent with performance in real driving conditions. A double-blind, placebo-controlled, two successive two-way crossover design was performed using cigarettes containing 20 mg of THC. Healthy occasional users of THC, aged 25-35 years, who had a consistent driving experience were included. The first two sessions were realized in simulation conditions, and the last two sessions were in real driving conditions. Driving performance was estimated through inappropriate line crossings (ILC) and the standard deviation of the vehicle's lateral position. Participants felt significantly drowsier and more tired after THC, whateve...Continue Reading

References

Dec 1, 1968·The British Journal of Social and Clinical Psychology·S B Eysenck, H J Eysenck
Oct 31, 2002·Human Psychopharmacology·C. T. J. Lamers, J. G. Ramaekers
Oct 31, 2002·Human Psychopharmacology·J. G. RamaekersJ. F. O'Hanlon
Jan 9, 2003·Trends in Cognitive Sciences·Andras Kemeny, Francesco Panerai
Jan 17, 2004·Drug and Alcohol Dependence·J G RamaekersO H Drummer
Jul 6, 2004·Sleep Medicine Reviews·Joris C VersterEdmund R Volkerts
Aug 31, 2004·The British Journal of Clinical Psychology·Pat McKennaNeil Frude
Jun 17, 2005·Life Sciences·Rebecca M Craft
Jun 7, 2006·Annals of Internal Medicine·Pierre PhilipBernard Bioulac
Mar 8, 2008·Journal of Safety Research·Wendy B StavDesiree N Lanford
May 8, 2008·Accident; Analysis and Prevention·Adi RonenDavid Shinar
Oct 14, 2008·Annales pharmaceutiques françaises·J-P GoulléC Lacroix
Apr 13, 2010·Accident; Analysis and Prevention·Michael G LennéJennifer R Redman
Jan 14, 2011·Journal of Sleep Research·Joris C VersterPierre Philip
Jun 28, 2011·Vision Research·Colas N Authié, Daniel R Mestre
Aug 9, 2011·Human Psychopharmacology·Monique A J MetsJoris C Verster
Jan 25, 2012·Accident; Analysis and Prevention·Con StoughEdward Ogden
Jan 25, 2012·Accident; Analysis and Prevention·D DavenneP Philip
Aug 9, 2012·Accident; Analysis and Prevention·Luke A DowneyCon Stough
Sep 7, 2012·PloS One·Kim Paula Colette KuypersAlain Gaston Verstraete
Nov 15, 2012·Accident; Analysis and Prevention·David HallvigTorbjörn Akerstedt
Dec 12, 2012·Clinical Chemistry·Rebecca L Hartman, Marilyn A Huestis
Sep 7, 2013·Accident; Analysis and Prevention·Agnès DauratPierre Philip
May 6, 2014·Accident; Analysis and Prevention·Toni M RudisillMotao Zhu
Jul 7, 2015·Drug and Alcohol Dependence·Rebecca L HartmanMarilyn A Huestis

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Citations

Aug 8, 2020·Journal of Primary Care & Community Health·Nicole WershovenCharles D MacLean
Feb 6, 2021·Psychopharmacology·Andrew FaresBruna Brands
Dec 9, 2020·International Journal of Environmental Research and Public Health·Sonia Ortiz-PeregrinaRosario G Anera
Mar 5, 2021·Accident; Analysis and Prevention·Tiana M CiccarelliMark A Ferro
May 1, 2021·International Journal of Environmental Research and Public Health·Sonia Ortiz-PeregrinaRosario G Anera
Aug 18, 2021·Accident; Analysis and Prevention·Ashley Brooks-RussellMichael J Kosnett
Oct 30, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joelle Perri-PlandéUNKNOWN French Addictovigilance Network

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