Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

Chemical Communications : Chem Comm
G MazzoccantiF Gasparrini

Abstract

By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.

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Citations

Feb 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea N L BatistaQuezia B Cass
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cinzia IngallinaLuisa Mannina
Apr 15, 2020·Analytical and Bioanalytical Chemistry·Cinzia CittiGiuseppe Cannazza
Jul 28, 2018·Analytical and Bioanalytical Chemistry·Caroline West
Feb 23, 2021·Cannabis and Cannabinoid Research·Crist N Filer
Jun 4, 2021·The Journal of Organic Chemistry·Alon R AguaMichael C Pirrung
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mattia SpanoAnatoly P Sobolev
Jun 13, 2021·Journal of Chromatography. a·Simona FellettiMartina Catani
Jul 27, 2021·Journal of Natural Products·Michael A SchafrothGiovanni Appendino
Jun 13, 2020·Journal of Medicinal Chemistry·Michael C Pirrung

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Methods Mentioned

BETA
circular dichroism

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