Cannabis use, depression and anxiety: A 3-year prospective population-based study

Journal of Affective Disorders
Anna-Karin DanielssonYvonne Forsell

Abstract

Whether or not cannabis use may increase the risk for depression and/or anxiety is not clear. For one thing, it has not been possible to draw a definitive conclusion regarding the direction of causality, i.e. whether cannabis use increases the risk for depression/anxiety or vice versa. This study aimed at examining possible associations between cannabis use, depression and anxiety, using all three measures as both exposure and outcome. Data were obtained from a longitudinal cohort study comprising 8598 Swedish men and women, aged 20-64, with a three-year-follow-up. Adjusted for sex and age, cannabis use at baseline was associated with an increased relative risk (RR) for depression and anxiety at follow-up, with RR=1.22 [1.06-1.42 Cl 95%] for depression and RR=1.38 [1.26-1.50 Cl 95%] for anxiety. Adjusted for all confounders (alcohol and illicit drug use, education, family tension, place of upbringing), the associations were no longer statistically significant; RR=0.99 [0.82-1.17 Cl 95%] for depression and RR=1.09 [0.98-1.20 Cl 95%] for anxiety. Age-adjusted, reporting depression or anxiety at baseline increased the risk of cannabis onset at follow-up three years later; RR=1.62 [1.28-2.03 CI 95%] and RR=1.63 [1.28-2.08 CI 95%] r...Continue Reading

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Citations

Mar 1, 2017·Depression and Anxiety·Maria M SteenkampWilliam T Anderson
Feb 23, 2019·European Journal of Pain : EJP·Marie-Odile KrebsTherese M Jay
Dec 24, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Aneta Przepiorka, Agata Blachnio
Oct 28, 2019·Journal of Dual Diagnosis·Lucia SideliRobin M Murray
Oct 9, 2019·Current Opinion in Psychiatry·Nadav Shalit, Shaul Lev-Ran
Jan 16, 2019·Current Addiction Reports·Aliya M LucatchTony P George
May 31, 2018·International Review of Psychiatry·Jacob T Borodovsky, Alan J Budney
Sep 26, 2019·Journal of Attention Disorders·Nieves Martínez-LunaJosep Antoni Ramos-Quiroga
May 4, 2017·Behavior Genetics·M SmolkinaM T Lynskey
Dec 20, 2018·European Archives of Psychiatry and Clinical Neuroscience·Darby J E LoweTony P George
Aug 14, 2019·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Megan WildesMarian Wilson
Jan 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Talise E MüllerDenis B Rosemberg
Oct 21, 2020·Drug and Alcohol Dependence·Rynaz RabieeAnna-Karin Danielsson
Jun 5, 2021·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Katelyn F RommCarla J Berg
Jul 10, 2021·The Journal of Behavioral Health Services & Research·Jacqueline SmithJoy Maddigan
Mar 6, 2021·Frontiers in Psychiatry·Maryam SorkhouTony P George

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