"Canonical and non-canonical actions of GRK5 in the heart"

Journal of Molecular and Cellular Cardiology
Christopher J TraynhamWalter J Koch

Abstract

As the average world-wide lifespan continues to increase, heart failure (HF) has dramatically increased in incidence leading to the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) play a prominent role in regulation of cardiovascular function. GPCRs are effectively "turned off" by GPCR kinases (GRKs) in a process known as "desensitization". GRKs 2 and 5 are highly expressed in the heart, and known to be upregulated in HF. Over the last 20years, the role of GRK2 in HF has been widely studied. However, until recently, the role of GRK5 in cardiac pathophysiology had yet to be elucidated. In the present review, we will focus on GRK5's role in the myocardium in normal physiology, and its apparent critical role in the progression of HF. Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in HF.

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Citations

May 18, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jonathan HullmannWalter J Koch
Mar 23, 2017·Journal of Cardiovascular Pharmacology·Sarah M Schumacher, Walter J Koch
Feb 22, 2018·Cell Death & Disease·Li-Ping JiangYong-Bin Chen
Mar 7, 2019·Frontiers in Pharmacology·Vsevolod V Gurevich, Eugenia V Gurevich
May 11, 2017·Frontiers in Pharmacology·Changbo ZhengXiaoqiang Yao
Sep 11, 2016·Molecular and Cellular Biochemistry·Cheon Ho ParkKwang-Seok Oh
Aug 1, 2020·International Journal of Molecular Sciences·Xi ChenPeisong Ma
Aug 28, 2020·Frontiers in Pharmacology·Natalia L Rukavina MikusicMariela M Gironacci
Mar 15, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Hitesh ShuklaAbdullah Sabyah
Sep 4, 2018·JACC. Basic to Translational Science·Laurel A GrisantiWalter J Koch
Jan 21, 2021·Cells·Marion LaudetteFrank Lezoualc'h
Jan 13, 2021·International Journal of Molecular Sciences·Gizem Kayki-Mutlu, Walter J Koch
Jan 15, 2021·Journal of Virology·Colleen L MayberryMelissa S Maginnis
Mar 7, 2021·International Journal of Molecular Sciences·Federica MarzanoAlessandro Cannavo
Jul 29, 2021·Cellular Signalling·Kellie A LemoineNicole H Purcell
Dec 21, 2019·ACS Medicinal Chemistry Letters·Rachel A RowlandsAndrew D White

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