Canonical Wnt signaling activity during synovial joint development.

Journal of Molecular Histology
Takashi YamagamiCheng-Ji Zhou

Abstract

Wnt signaling plays important roles in skeletal development. However, the activation and function of canonical Wnt signaling in joint development remains unclear. We analyzed the lineage identity and developmental changes of the Wnt-responsive cells during synovial joint formation as well as adulthood in the Wnt signaling reporter TOPgal transgenic mice. At embryonic day (E) 12.5, we found that the TOPgal was inactivated in the presumptive joint forming interzone, but it was intensively activated in the cartilage anlage of developing long bones and digits. At E14.5, the TOPgal activity was found in a subgroup of the articular chondrocyte lineage cells, which were co-immunolabeled with Doublecortin intensively and with Vinculin weakly. At E18.5, the TOPgal/Doublecortin co-immunolabeled cells were found in the superficial layer of the developing articular cartilage. During postnatal development, the TOPgal(+) articular chondrocytes were abundant at P7 and decreased from P10. A small number of TOPgal(+) articular chondrocytes were also found in adult joints. Our study suggests an age- and lineage-specific role of canonical Wnt signaling in joint development and maintenance.

References

Apr 20, 1999·Developmental Biology·E E Storm, D M Kingsley
Apr 24, 2002·Developmental Cell·Gerard Karsenty, Erwin F Wagner
May 16, 2003·Nature·Henry M Kronenberg
Sep 6, 2003·Birth Defects Research. Part C, Embryo Today : Reviews·Charles W ArcherPhilippa Francis-West
Sep 12, 2003·Developmental Cell·Michael T VeemanRandall T Moon
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Yingzi Yang
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Feb 10, 2006·Trends in Cell Biology·Christine Hartmann
May 4, 2006·The Journal of Clinical Investigation·Venkatesh KrishnanOrmond A Macdougald
Jun 24, 2006·The Journal of Biological Chemistry·Michael D Gordon, Roel Nusse
Nov 23, 2006·European Cells & Materials·D SpäterC Hartmann
Nov 23, 2006·Current Topics in Developmental Biology·Roland BaronSergio Roman-Roman
Sep 28, 2007·Biochemical and Biophysical Research Communications·Yi ZhangZongbing You
Jan 1, 2008·Cellular Signalling·Fei LiuCun-Yu Wang
Jan 23, 2008·The Journal of Cell Biology·Elaine Fuchs
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Timothy F Day, Yingzi Yang
Aug 30, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A A Pitsillides, Doreen E Ashhurst
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ya-Zhou WangCheng-Ji Zhou
Oct 1, 2008·Seminars in Cell & Developmental Biology·P LeuchtJ A Helms
Aug 5, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chengji J ZhouKai Wang

❮ Previous
Next ❯

Citations

Mar 20, 2012·Cell and Tissue Research·Ikumi MichikamiMakoto Abe
Apr 25, 2014·International Journal of Molecular Sciences·Dongxia GeZongbing You
Dec 6, 2011·Arthritis and Rheumatism·Melissa M MatzelleEllen M Gravallese
Jun 16, 2019·Cellular and Molecular Life Sciences : CMLS·Ryota Chijimatsu, Taku Saito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.