Canthaxanthin retinopathy without intake of canthaxanthin

Klinische Monatsblätter für Augenheilkunde
J A OosterhuisF A de Wolff

Abstract

Seven patients are described who presented with the typical fundus finding of gold-colored crystals in the superficial layers of retina in the macular area (characteristic of canthaxanthin retinopathy) without having taken canthaxanthin-containing drugs. Canthaxanthin used as a food additive is discussed as a possible cause of the crystal deposition. There may be a rather high individual tendency to develop crystal deposition, possibly related to a metabolic defect affecting canthaxanthin kinetics or to pre-existing changes in the retinal pigment epithelium. In one patient a slight decrease in crystalline deposition was observed in the course of four years.

Citations

Dec 1, 2015·Food Chemistry·Raphael C Mordi, John C Walton
Jun 14, 2005·Biochimica Et Biophysica Acta·Agnieszka SujakWiesław I Gruszecki
Oct 1, 1990·Acta Ophthalmologica·H LeyonP Algvere

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